A single-electrode electrochemical system for multiplex electrochemiluminescence analysis based on a resistance induced potential difference

Developing low-cost and simple electrochemical systems is becoming increasingly important but still challenged for multiplex experiments. Here we report a single-electrode electrochemical system (SEES) using only one electrode not only for a single experiment but also for multiplex experiments based...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2018-04, Vol.9 (16), p.3911-3916
Main Authors: Gao, Wenyue, Muzyka, Kateryna, Ma, Xiangui, Lou, Baohua, Xu, Guobao
Format: Article
Language:English
Subjects:
Chemistry
Cost analysis
Electrochemiluminescence
Electrochemistry
Electrodes
Experiments
Microelectromechanical systems
Multiplexing
Sensitivity analysis
Smartphones
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Summary:Developing low-cost and simple electrochemical systems is becoming increasingly important but still challenged for multiplex experiments. Here we report a single-electrode electrochemical system (SEES) using only one electrode not only for a single experiment but also for multiplex experiments based on a resistance induced potential difference. SEESs for a single experiment and multiplex experiments are fabricated by attaching a self-adhesive label with a hole and multiple holes onto an ITO electrode, respectively. This enables multiplex electrochemiluminescence analysis with high sensitivity at a very low safe voltage using a smartphone as a detector. For the multiplex analysis, the SEES using a single electrode is much simpler, cheaper and more user-friendly than conventional electrochemical systems and bipolar electrochemical systems using electrode arrays. Moreover, SEESs are free from the electrochemiluminescent background problem from driving electrodes in bipolar electrochemical systems. Since numerous electrodes and cover materials can be used to fabricate SEESs readily and electrochemistry is being extensively used, SEESs are very promising for broad applications, such as drug screening and high throughput analysis. A single-electrode electrochemical system uses only one electrode for multiplex experiments, and is a highly cheap platform for high throughput analysis.
ISSN:2041-6520
2041-6539
DOI:10.1039/c8sc00410b