Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment

In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data...

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Published in:Critical reviews in food science and nutrition 2018-05, Vol.58 (8), p.1391-1405
Main Authors: Russo, Maria, Spagnuolo, Carmela, Russo, Gian Luigi, Skalicka-Woźniak, Krystyna, Daglia, Maria, Sobarzo-Sánchez, Eduardo, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad
Format: Article
Language:English
Subjects:
Angiogenesis
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Apoptosis
Brassica
Brassica - chemistry
Cancer
Cancer therapies
Cell cycle
Deoxyribonucleic acid
DNA
DNA damage
Gene Expression Regulation - drug effects
Homeostasis
Humans
Isothiocyanate
Isothiocyanates - pharmacology
Metastases
Molecular chains
Neoplasms - drug therapy
NF-E2-Related Factor 2 - genetics
NF-E2-Related Factor 2 - metabolism
Sulforaphane
Therapy
Transcription activation
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Summary:In the past decades, extensive studies have reported the potential chemopreventive activity of sulforaphane, an isothiocyanate derived from glucoraphanin, occurring in large amounts in Brassica genus plants. Sulforaphane was found to be active against several forms of cancer. A growing body of data shows that sulforaphane acts against cancer at different levels, from development to progression, through pleiotropic effects. In this review, we discuss the available experimental and clinical data on the potential therapeutic role of sulforaphane against cancer. Its effects range from the protection of cells from DNA damage to the modulation of the cell cycle via pro-apoptotic, anti-angiogenesis and anti-metastasis activities. At molecular level, sulforaphane modulates cellular homeostasis via the activation of the transcription factor Nrf2. Although data from clinical studies are limited, sulforaphane remains a good candidate in the adjuvant therapy based on natural molecules against several types of cancer.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2016.1259983