Harnessing chondroitin sulphate in composite scaffolds to direct progenitor and stem cell function for tissue repair

The development of bioscaffolds that incorporate chondroitin sulphate (CS) and their applications with progenitor and stem cells in cartilage, bone, cornea, skin, and neural repair are reviewed. CS is a heterogeneous structure due to the organisation of multiple CS disaccharide sulphation motifs, gi...

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Bibliographic Details
Published in:Biomaterials science 2018-05, Vol.6 (5), p.947-957
Main Authors: Farrugia, B. L, Lord, M. S, Whitelock, J. M, Melrose, J
Format: Article
Language:English
Subjects:
Biological activity
Cartilage
Cornea
Heterogeneous structure
Molecular chains
Regeneration
Repair
Scaffolds
Skin
Stem cells
Sulfation
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Summary:The development of bioscaffolds that incorporate chondroitin sulphate (CS) and their applications with progenitor and stem cells in cartilage, bone, cornea, skin, and neural repair are reviewed. CS is a heterogeneous structure due to the organisation of multiple CS disaccharide sulphation motifs, giving rise to a vast range of CS chain structures, and hence the wide range of biological activity. The incorporation of this biological molecule represents a significant advance in bioscaffold design and performance in tissue repair strategies. The intrinsic stem-cell directive properties of CS are covered in the context of tissue development, and the differing CS disaccharide motifs, referred to as the 'glyco-code'. These structural motifs contribute to stem cell proliferation and differentiation in the scaffold environment and improve outcomes in terms of tissue repair or regeneration worthy of future research. This review details the inclusion of chondroitin sulphate in bioscaffolds for superior functional properties in tissue regenerative applications.
ISSN:2047-4830
2047-4849
DOI:10.1039/c7bm01158j