Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones

A facile TBHP-mediated direct oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes has been developed under metal-free conditions. This method provided a convenient and efficient approach to various 3-acylated quinoxalin-2(1H)-ones from readily available starting materials with excellent r...

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Published in:Organic & biomolecular chemistry 2018, Vol.16 (17), p.3203-3212
Main Authors: Yuan, Jin-Wei, Fu, Jun-Hao, Liu, Shuai-Nan, Xiao, Yong-Mei, Mao, Pu, Qu, Ling-Bo
Format: Article
Language:English
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Coupling
Functional groups
Metals
Regioselectivity
Substrates
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description A facile TBHP-mediated direct oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes has been developed under metal-free conditions. This method provided a convenient and efficient approach to various 3-acylated quinoxalin-2(1H)-ones from readily available starting materials with excellent regioselectivity. This reaction proceeded efficiently under mild conditions over a broad range of substrates and with functional group tolerance.
doi_str_mv 10.1039/c8ob00206a
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subjects Coupling
Functional groups
Metals
Regioselectivity
Substrates
title Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones
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