Mechanochemical Cobalt‐Catalyzed C−H Bond Functionalizations by Ball Milling

Ball milling techniques have been applied in the development of a mechanosynthesis of [Cp*Co(CO)I2], which proved highly efficient as catalyst in mechanochemical C−H bond amidations of indoles in a mixer ball mill. A wide range of amidated products is obtained in excellent yields. Compared to the so...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-05, Vol.360 (9), p.1800-1804
Main Authors: Cheng, Hanchao, Hernández, José G., Bolm, Carsten
Format: Article
Language:English
Subjects:
Amidation
ball mill
Ball milling
Catalysis
Catalysts
Cobalt
C−H bond functionalization
Hydrogen bonds
Indoles
mechanosynthesis
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Summary:Ball milling techniques have been applied in the development of a mechanosynthesis of [Cp*Co(CO)I2], which proved highly efficient as catalyst in mechanochemical C−H bond amidations of indoles in a mixer ball mill. A wide range of amidated products is obtained in excellent yields. Compared to the solution‐based methods, the procedure opens a more feasible and environmentally‐friendly access to both the cobalt(III) catalyst and 2‐amidated indoles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800161