Demonstration of cellular imaging by using luminescent and anti-cytotoxic europium-doped hafnia nanocrystals

Luminescent nanoparticles are researched for their potential impact in medical science, but no materials approved for parenteral use have been available so far. To overcome this issue, we demonstrate that Eu 3+ -doped hafnium dioxide nanocrystals can be used as non-toxic, highly stable probes for ce...

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Bibliographic Details
Published in:Nanoscale 2018-05, Vol.1 (17), p.7933-794
Main Authors: Villa, Irene, Villa, Chiara, Monguzzi, Angelo, Babin, Vladimir, Tervoort, Elena, Nikl, Martin, Niederberger, Markus, Torrente, Yvan, Vedda, Anna, Lauria, Alessandro
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biocompatible Materials
Biomedical materials
Cell Line
Cytotoxicity
Europium
Europium - chemistry
Hafnium - chemistry
Hafnium oxide
Luminescence
Luminescent Measurements
Medical materials
Medical research
Medical science
Mice
Nanocrystals
Nanoparticles - chemistry
Reactive Oxygen Species - chemistry
Viability
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Summary:Luminescent nanoparticles are researched for their potential impact in medical science, but no materials approved for parenteral use have been available so far. To overcome this issue, we demonstrate that Eu 3+ -doped hafnium dioxide nanocrystals can be used as non-toxic, highly stable probes for cellular optical imaging and as radiosensitive materials for clinical treatment. Furthermore, viability and biocompatibility tests on artificially stressed cell cultures reveal their ability to buffer reactive oxygen species, proposing an anti-cytotoxic feature interesting for biomedical applications. The first use of Eu 3+ -doped hafnium dioxide nanocrystals for optical imaging of cellular systems is reported.
ISSN:2040-3364
2040-3372
DOI:10.1039/c8nr00724a