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Preparation of gelatin nanoparticles by two step desolvation method for application in photodynamic therapy

Gelatin nanoparticles have recently been receiving considerable attention because they offer a good option as release systems due to their low cost, biocompatibility, biodegradability and its application in several types of formulations. This study aim was to evaluate the potential application of ge...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2018-08, Vol.29 (11), p.1287-1301
Main Authors: Carvalho, Janicy Arantes, Abreu, Alexandro Silva, Ferreira, Vitória Tonini Porto, Gonçalves, Erika Peterson, Tedesco, Antonio Claudio, Pinto, Juliana Guerra, Ferreira-Strixino, Juliana, Beltrame Junior, Milton, Simioni, Andreza Ribeiro
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Language:English
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Summary:Gelatin nanoparticles have recently been receiving considerable attention because they offer a good option as release systems due to their low cost, biocompatibility, biodegradability and its application in several types of formulations. This study aim was to evaluate the potential application of gelatin nanoparticles entrapping a photosensitizer in Photodynamic Therapy. Gelatin nanoparticles were studied by steady-state techniques and the biological activity evaluated by in vitro MTT assay. The particles were spherical in shape exhibiting a 273 nm diameter with a low tendency to aggregate. The loading efficiency was 76%. Photosensitizer photophysical properties were shown to be preserved after GN encapsulation. The cells viability obtaining 85% cells death compared with control. The results demonstrate that gelatin nanoparticles can be successfully applied for photosensitizers encapsulation or other active drugs and be used as an optimal medium for a variety of bioactive materials, which can also be encapsulated by the proposed method.
ISSN:0920-5063
1568-5624
DOI:10.1080/09205063.2018.1456027