Variations in clinical management of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation according to different equations for estimating renal function

Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft–Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for es...

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Bibliographic Details
Published in:Internal and emergency medicine 2018-10, Vol.13 (7), p.1059-1067
Main Authors: Malavasi, Vincenzo Livio, Pettorelli, Daniele, Fantecchi, Elisa, Zoccali, Cristina, Laronga, Giuliana, Trenti, Tommaso, Gregory Yoke Hong Lip, Boriani, Giuseppe
Format: Article
Language:English
Subjects:
Antagonist drugs
Anticoagulants
Body mass
Cardiac arrhythmia
Creatinine
Fibrillation
Geriatrics
Glomerular filtration rate
Kidneys
Males
Management
Mathematical models
Older people
Renal function
Vitamin K
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Summary:Prescription of non-vitamin K antagonist oral anticoagulants (NOACs) requires an assessment of renal function (RF) and the Cockcroft–Gault (CG) equation is traditionally recommended. The objective of the study was to evaluate the potential changes in NOACs management using different equations for estimating RF. In a post hoc analysis of a prospective cohort of patients with atrial fibrillation, we considered different equations: (1) CG for creatinine clearance (CrCl), (2) modification of diet in renal disease (MDRD), (3) CKD-EPI, (4) Berlin Initiative Study 1 (BIS-1) and (5) full age spectrum (FAS), for glomerular filtration rate (GFR). RF was classified according to CrCl in three categories: severely depressed (SD-RF) 
ISSN:1828-0447
1970-9366
DOI:10.1007/s11739-018-1857-3