0009 A Comparison of the Effects of Gaboxadol and Sleep Restriction on Sleep Depth Assessed by the Odds-Ratio-Product

• Published in: Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A3-A4
• Main Authors: Walsh, J K, Schweitzer, P K, Griffin, K S, Younes, M
• Format: Article
• Language: English
• Subjects: Sleep
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsy061.008

Abstract Introduction Several studies have shown dose-related increases in SWS and low frequency EEG power and reduced wake time and awakenings with gaboxadol (GBX). These changes are similar to those seen with sleep loss, suggesting that GBX may enhance sleep depth. Odds-Ratio-Product (ORP) is a unit-less continuous measure of the relative power in four EEG frequency bands, with values ranging from 0 (deep sleep) to 2.5 (full wakefulness). Excellent correlation was reported between current ORP and probability of arousal in the next 30 seconds (r2=0.98), suggesting that ORP is related to sleep depth. We evaluated the effects of sleep restriction (SR) alone or with GBX on sleep depth using ORP. Methods Forty-one subjects underwent two baseline PSGs followed by four SR nights (5h) with either placebo (21 subjects) or 15 mg GBX (20 subjects). We compared the change from baseline night 2 (first 5h) to SR night 1 and SR night 4 using two measures: ORP during TST and arousal index. Results During the first SR night, ORP and arousal index did not change with SR alone (-0.01 ± 0.09 and 0.2 ± 3.0/h for ORP and arousal index, respectively; P>.6 for both), but decreased significantly with GBX (-0.11 ± 0.09 and -3.7 ± 5.2/h; P