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1005 Sleep Disturbances In Opioid Dependent Patients On Buprenorphine- Gender Differences
Abstract Introduction Sleep disturbances are common in opioid use disorder (OUD) patients on buprenorphine. The aim of the study is to examine gender differences in the prevalence and factors associated with sleep disturbances in patients with OUDs on buprenorphine. Methods A total of 219 patients w...
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| Published in: | Sleep (New York, N.Y.) N.Y.), 2018-04, Vol.41 (suppl_1), p.A372-A372 |
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| container_title | Sleep (New York, N.Y.) |
| container_volume | 41 |
| creator | Basappa Krishnamurthy, V Coffey, A Sanjay, Y Singh, J Kong, L Fernandez Mendoza, J Vgontzas, A Bixler, E Roger, M |
| description | Abstract
Introduction
Sleep disturbances are common in opioid use disorder (OUD) patients on buprenorphine. The aim of the study is to examine gender differences in the prevalence and factors associated with sleep disturbances in patients with OUDs on buprenorphine.
Methods
A total of 219 patients with OUDs on buprenorphine (35 ± 9.5 years, 49.3% women, 80% Caucasian) were recruited from a buprenorphine maintenance program in central Pennsylvania. Subjects completed a sociodemographic survey and the Pittsburgh Sleep Quality Index (PSQI). We used chi-square tests, t-tests, and Mann-Whitney U tests to compare demographics, sleep disturbances, and PSQI composite scores between men and women. Stepwise logistic regression analysis was performed to determine factors associated with poor sleep quality in men and women separately.
Results
Women were more likely to report moderate-to-severe depression (42 %) and anxiety (53%) and to seek treatment for mental health issues (39 %) than men (24%, 36% and 19%, respectively, all Ps |
| doi_str_mv | 10.1093/sleep/zsy061.1004 |
| format | article |
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Introduction
Sleep disturbances are common in opioid use disorder (OUD) patients on buprenorphine. The aim of the study is to examine gender differences in the prevalence and factors associated with sleep disturbances in patients with OUDs on buprenorphine.
Methods
A total of 219 patients with OUDs on buprenorphine (35 ± 9.5 years, 49.3% women, 80% Caucasian) were recruited from a buprenorphine maintenance program in central Pennsylvania. Subjects completed a sociodemographic survey and the Pittsburgh Sleep Quality Index (PSQI). We used chi-square tests, t-tests, and Mann-Whitney U tests to compare demographics, sleep disturbances, and PSQI composite scores between men and women. Stepwise logistic regression analysis was performed to determine factors associated with poor sleep quality in men and women separately.
Results
Women were more likely to report moderate-to-severe depression (42 %) and anxiety (53%) and to seek treatment for mental health issues (39 %) than men (24%, 36% and 19%, respectively, all Ps<0.01). Men had longer duration of opioid dependence (128 ± 102 months) and frequent rehabilitation hospitalizations (3 ± 3.5) than women (88 ± 66 months, and 2 ± 2 respectively, all Ps<0.01). Women had marginally longer duration of abstinence (33 ± 46 months) and adherence to medication treatment (19 ± 28 months) on buprenorphine than men (23 ± 31 months and 13 ± 19 months respectively, all Ps<0.10). Women had higher total PSQI scores (10.7 ± 4.8) and more frequent poor sleep quality (PSQI>5) (82%) than men (8.7 ± 4.3 and 69% respectively, p<0.05). In men, anxiety severity (OR=1.9, p=0.03) was independently associated with poor sleep quality. In women, age (OR=1.2, p=0.01) anxiety severity (OR=3.2, p=0.005) worsening sleep with opioid use (OR=6.3, p=0.008) were independently associated with poor sleep quality.
Conclusion
Similar to the general population, women with OUDs on buprenorphine are more likely to have severe and frequent sleep disturbances than men. Age, presence of comorbid anxiety and onset of insomnia with opioid use may help predict sleep disturbance in women with OUDs on buprenorphine. Recognizing and treating sleep disturbances as well as anxiety in men and women with OUDs on buprenorphine should be a target for relapse prevention.
Support (If Any)
Department of Psychiatry, Penn State College of Medicine.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsy061.1004</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Anxiety ; Chi-square test ; Gender differences ; Narcotics ; Quality ; Women</subject><ispartof>Sleep (New York, N.Y.), 2018-04, Vol.41 (suppl_1), p.A372-A372</ispartof><rights>Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 Sleep Research Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Basappa Krishnamurthy, V</creatorcontrib><creatorcontrib>Coffey, A</creatorcontrib><creatorcontrib>Sanjay, Y</creatorcontrib><creatorcontrib>Singh, J</creatorcontrib><creatorcontrib>Kong, L</creatorcontrib><creatorcontrib>Fernandez Mendoza, J</creatorcontrib><creatorcontrib>Vgontzas, A</creatorcontrib><creatorcontrib>Bixler, E</creatorcontrib><creatorcontrib>Roger, M</creatorcontrib><title>1005 Sleep Disturbances In Opioid Dependent Patients On Buprenorphine- Gender Differences</title><title>Sleep (New York, N.Y.)</title><description>Abstract
Introduction
Sleep disturbances are common in opioid use disorder (OUD) patients on buprenorphine. The aim of the study is to examine gender differences in the prevalence and factors associated with sleep disturbances in patients with OUDs on buprenorphine.
Methods
A total of 219 patients with OUDs on buprenorphine (35 ± 9.5 years, 49.3% women, 80% Caucasian) were recruited from a buprenorphine maintenance program in central Pennsylvania. Subjects completed a sociodemographic survey and the Pittsburgh Sleep Quality Index (PSQI). We used chi-square tests, t-tests, and Mann-Whitney U tests to compare demographics, sleep disturbances, and PSQI composite scores between men and women. Stepwise logistic regression analysis was performed to determine factors associated with poor sleep quality in men and women separately.
Results
Women were more likely to report moderate-to-severe depression (42 %) and anxiety (53%) and to seek treatment for mental health issues (39 %) than men (24%, 36% and 19%, respectively, all Ps<0.01). Men had longer duration of opioid dependence (128 ± 102 months) and frequent rehabilitation hospitalizations (3 ± 3.5) than women (88 ± 66 months, and 2 ± 2 respectively, all Ps<0.01). Women had marginally longer duration of abstinence (33 ± 46 months) and adherence to medication treatment (19 ± 28 months) on buprenorphine than men (23 ± 31 months and 13 ± 19 months respectively, all Ps<0.10). Women had higher total PSQI scores (10.7 ± 4.8) and more frequent poor sleep quality (PSQI>5) (82%) than men (8.7 ± 4.3 and 69% respectively, p<0.05). In men, anxiety severity (OR=1.9, p=0.03) was independently associated with poor sleep quality. In women, age (OR=1.2, p=0.01) anxiety severity (OR=3.2, p=0.005) worsening sleep with opioid use (OR=6.3, p=0.008) were independently associated with poor sleep quality.
Conclusion
Similar to the general population, women with OUDs on buprenorphine are more likely to have severe and frequent sleep disturbances than men. Age, presence of comorbid anxiety and onset of insomnia with opioid use may help predict sleep disturbance in women with OUDs on buprenorphine. Recognizing and treating sleep disturbances as well as anxiety in men and women with OUDs on buprenorphine should be a target for relapse prevention.
Support (If Any)
Department of Psychiatry, Penn State College of Medicine.</description><subject>Anxiety</subject><subject>Chi-square test</subject><subject>Gender differences</subject><subject>Narcotics</subject><subject>Quality</subject><subject>Women</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNkMFOwzAQRC0EEqXwAdwscSXUm9hOcoS2lEqVigQcOFmpsxapimPs5FC-HofwAZxGu_tmVhpCroHdASuzWTggutl3ODIJccP4CZmAECwp4_mUTBhISApg4pxchLBnceZlNiHvkRX0ZXDTRRO63u8qqzHQtaVb17RNTRfo0NZoO_pcdU3UQLeWPvTOo229-2gsJnQ1ID5GGINxHxMuyZmpDgGv_nRK3h6Xr_OnZLNdref3m0SDYDzhuii15DswWZprliKautylPM2F1EVeVVqUnOVGAArDdMo108CxrnkqDdaQTcnNmOt8-9Vj6NS-7b2NL1XKMillCaKIFIyU9m0IHo1yvvms_FEBU0OD6rdBNTaohgaj53b0tL37B_4D9Zt0Vw</recordid><startdate>20180427</startdate><enddate>20180427</enddate><creator>Basappa Krishnamurthy, V</creator><creator>Coffey, A</creator><creator>Sanjay, Y</creator><creator>Singh, J</creator><creator>Kong, L</creator><creator>Fernandez Mendoza, J</creator><creator>Vgontzas, A</creator><creator>Bixler, E</creator><creator>Roger, M</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20180427</creationdate><title>1005 Sleep Disturbances In Opioid Dependent Patients On Buprenorphine- Gender Differences</title><author>Basappa Krishnamurthy, V ; Coffey, A ; Sanjay, Y ; Singh, J ; Kong, L ; Fernandez Mendoza, J ; Vgontzas, A ; Bixler, E ; Roger, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1504-4c89c64b1f327c02eefd9b242756c87aac59407f51e5f0c24c0c14edd426fed13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anxiety</topic><topic>Chi-square test</topic><topic>Gender differences</topic><topic>Narcotics</topic><topic>Quality</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basappa Krishnamurthy, V</creatorcontrib><creatorcontrib>Coffey, A</creatorcontrib><creatorcontrib>Sanjay, Y</creatorcontrib><creatorcontrib>Singh, J</creatorcontrib><creatorcontrib>Kong, L</creatorcontrib><creatorcontrib>Fernandez Mendoza, J</creatorcontrib><creatorcontrib>Vgontzas, A</creatorcontrib><creatorcontrib>Bixler, E</creatorcontrib><creatorcontrib>Roger, M</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basappa Krishnamurthy, V</au><au>Coffey, A</au><au>Sanjay, Y</au><au>Singh, J</au><au>Kong, L</au><au>Fernandez Mendoza, J</au><au>Vgontzas, A</au><au>Bixler, E</au><au>Roger, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1005 Sleep Disturbances In Opioid Dependent Patients On Buprenorphine- Gender Differences</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2018-04-27</date><risdate>2018</risdate><volume>41</volume><issue>suppl_1</issue><spage>A372</spage><epage>A372</epage><pages>A372-A372</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Abstract
Introduction
Sleep disturbances are common in opioid use disorder (OUD) patients on buprenorphine. The aim of the study is to examine gender differences in the prevalence and factors associated with sleep disturbances in patients with OUDs on buprenorphine.
Methods
A total of 219 patients with OUDs on buprenorphine (35 ± 9.5 years, 49.3% women, 80% Caucasian) were recruited from a buprenorphine maintenance program in central Pennsylvania. Subjects completed a sociodemographic survey and the Pittsburgh Sleep Quality Index (PSQI). We used chi-square tests, t-tests, and Mann-Whitney U tests to compare demographics, sleep disturbances, and PSQI composite scores between men and women. Stepwise logistic regression analysis was performed to determine factors associated with poor sleep quality in men and women separately.
Results
Women were more likely to report moderate-to-severe depression (42 %) and anxiety (53%) and to seek treatment for mental health issues (39 %) than men (24%, 36% and 19%, respectively, all Ps<0.01). Men had longer duration of opioid dependence (128 ± 102 months) and frequent rehabilitation hospitalizations (3 ± 3.5) than women (88 ± 66 months, and 2 ± 2 respectively, all Ps<0.01). Women had marginally longer duration of abstinence (33 ± 46 months) and adherence to medication treatment (19 ± 28 months) on buprenorphine than men (23 ± 31 months and 13 ± 19 months respectively, all Ps<0.10). Women had higher total PSQI scores (10.7 ± 4.8) and more frequent poor sleep quality (PSQI>5) (82%) than men (8.7 ± 4.3 and 69% respectively, p<0.05). In men, anxiety severity (OR=1.9, p=0.03) was independently associated with poor sleep quality. In women, age (OR=1.2, p=0.01) anxiety severity (OR=3.2, p=0.005) worsening sleep with opioid use (OR=6.3, p=0.008) were independently associated with poor sleep quality.
Conclusion
Similar to the general population, women with OUDs on buprenorphine are more likely to have severe and frequent sleep disturbances than men. Age, presence of comorbid anxiety and onset of insomnia with opioid use may help predict sleep disturbance in women with OUDs on buprenorphine. Recognizing and treating sleep disturbances as well as anxiety in men and women with OUDs on buprenorphine should be a target for relapse prevention.
Support (If Any)
Department of Psychiatry, Penn State College of Medicine.</abstract><cop>US</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsy061.1004</doi><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Online; Alma/SFX Local Collection |
| subjects | Anxiety Chi-square test Gender differences Narcotics Quality Women |
| title | 1005 Sleep Disturbances In Opioid Dependent Patients On Buprenorphine- Gender Differences |
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