DNA replication licensing factor MCM2, geminin, and Ki67 define proliferative state and are linked with survival in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is still an unabated global killer with little advancement in its survival rate. DNA replication licensing proteins and Aurora kinase A are biomarkers that play important roles in genomic stability. The expression profile of minichromosomal maintenance protein 2 (...

Full description

Saved in:
Bibliographic Details
Published in:European journal of oral sciences 2018-06, Vol.126 (3), p.186-196
Main Authors: Al‐Hazmi, Nadia, Alhazzazi, Turki, Williams, Gareth, Stoeber, Kai, Al‐Dabbagh, Raghad
Format: Article
Language:English
Subjects:
Aurora kinase
Aurorakinases
Biomarkers
Cell survival
Decision analysis
Deoxyribonucleic acid
DNA
DNA biosynthesis
Geminin
Gene expression
Invasiveness
Licenses
Licensing
licensing proteins
Oral cancer
Oral squamous cell carcinoma
Polyps
prognosis
Proteins
Replication
Squamous cell carcinoma
Survival
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oral squamous cell carcinoma (OSCC) is still an unabated global killer with little advancement in its survival rate. DNA replication licensing proteins and Aurora kinase A are biomarkers that play important roles in genomic stability. The expression profile of minichromosomal maintenance protein 2 (MCM2), Ki67, geminin, and Aurora‐A were linked to clinicopathological and outcome parameters, survival, and DNA content in 125 cases of OSCC. Oral fibroepithelial polyps (OFEP) were controls. The OSCC tumour cells were in a rapidly proliferating state, as assessed by the increased expression profile of MCM2, Ki67, geminin, and Aurora‐A and of the geminin/Ki67 ratio, and the decrease of the MCM2/Ki67 ratio, in OSCC compared with OFEP (P 
ISSN:0909-8836
1600-0722
DOI:10.1111/eos.12420