Molecular subtypes of head and neck cancer predict response to cetuximab treatment

An abstract of the study conducted by Klinghammer et al establishing different molecular subtypes of head and neck cancer based on gene expression patterns as predictive signature for an EFGR directed treatment. The study concluded that the basal subtype was a strong predictor for response to EGFR d...

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Bibliographic Details
Published in:European journal of cancer (1990) 2016-12, Vol.69, p.S53-S53
Main Authors: Klinghammer, K, Otto, R, Raguse, J.D, Albers, A, Fichtner, I, Keilholz, U, Hoffmann, J
Format: Article
Language:English
Subjects:
Cancer
Chemotherapy
Epidermal growth factor receptors
Gene expression
Head & neck cancer
Hematology, Oncology and Palliative Medicine
Medical treatment
Molecular chains
Monoclonal antibodies
Targeted cancer therapy
Xenografts
Xenotransplantation
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Summary:An abstract of the study conducted by Klinghammer et al establishing different molecular subtypes of head and neck cancer based on gene expression patterns as predictive signature for an EFGR directed treatment. The study concluded that the basal subtype was a strong predictor for response to EGFR directed therapy in head and neck squamous cell cancer patient derived xenografts, whereas activity of chemotherapy was homogenous between signature-defined subtypes.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(16)32744-7