Metacycloprodigiosin (mcPG) induced cell death selectively in β-catenin mutated tumor cells

An abstract of the study by Ikeda et al screening for compounds that induced apoptosis selectively in β-catenin mutated tumor cells is presented. In this study, they screened more than 2,000 microbial extracts for the compounds that induced apoptosis in β-catenin mutated HCT116 cells, but not in A37...

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Bibliographic Details
Published in:European journal of cancer (1990) 2016-12, Vol.69, p.S79
Main Authors: Ikeda, H, Shikata, Y, Tashiro, E, Imoto, M
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Apoptosis
Cancer
Cell death
H+-transporting ATPase
Medical screening
Microorganisms
Mutation
Tumor cell lines
Tumor cells
Tumors
β-Catenin
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Summary:An abstract of the study by Ikeda et al screening for compounds that induced apoptosis selectively in β-catenin mutated tumor cells is presented. In this study, they screened more than 2,000 microbial extracts for the compounds that induced apoptosis in β-catenin mutated HCT116 cells, but not in A375 cells harboring wild type β-catenin. Results, they found one streptomyces strain produced such active compound. Furthermore, V-ATPase inhibitors induced apoptosis selectively in β-catenin mutated tumor cell lines.
ISSN:0959-8049
1879-0852