Highly antiproliferative neutral Ru(ii)-arene phosphine complexes

Six ruthenium( ii )- and four gold( i )-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru( ii ) complexes displayed an IC 50 of around 2...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2018, Vol.42 (1), p.815-8112
Main Authors: Chotard, Florian, Dondaine, Lucile, Balan, Cédric, Bettaïeb, Ali, Paul, Catherine, Le Gendre, Pierre, Bodio, Ewen
Format: Article
Language:English
Subjects:
Antiproliferatives
Colon
Gold
Ruthenium
Ruthenium compounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Six ruthenium( ii )- and four gold( i )-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru( ii ) complexes displayed an IC 50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced. The introduction of a benzoate ligand dramatically increases the ruthenium uptake in cells, leading to a low micromolar IC 50 .
ISSN:1144-0546
1369-9261
DOI:10.1039/c7nj04442a