Iron(III) Porphyrin Catalyzed Olefination of Aldehydes with 2,2,2‐Trifluorodiazoethane (CF3CHN2)

An efficient method for the iron(III) porphyrin catalyzed olefination of various aldehydes with 2,2,2‐trifluorodiazoethane under neutral conditions is described. This transformation was shown to have a broad substrate scope and provide the corresponding CF3‐substituted alkenes in good yields. The nu...

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Bibliographic Details
Published in:European journal of organic chemistry 2018-05, Vol.2018 (18), p.2082-2090
Main Authors: Lu, Yang, Huang, Chuyu, Liu, Chao, Guo, Yong, Chen, Qing‐Yun
Format: Article
Language:English
Subjects:
Aldehydes
Alkenes
Fluorine
Iron
Olefination
Porphyrins
Substrates
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Summary:An efficient method for the iron(III) porphyrin catalyzed olefination of various aldehydes with 2,2,2‐trifluorodiazoethane under neutral conditions is described. This transformation was shown to have a broad substrate scope and provide the corresponding CF3‐substituted alkenes in good yields. The number of equivalents of PPh3 that is used in this reaction is crucial to the success of the olefination process. This reaction is a useful supplement to the synthetic applications of CF3CHN2. An efficient method for the iron(III) porphyrin catalyzed olefination of various aldehydes with 2,2,2‐trifluorodiazoethane (CF3CHN2) under neutral conditions has been developed. This reaction is an important supplement to the synthetic applications of CF3CHN2.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201800325