In vitro assessment of neurotoxicity and neuroinflammation of homemade MWCNTs

[Display omitted] •PMWCNT and fMWCNT triggered cyto- and geno-toxic effects in neuronal-like cells.•IL-1β, IL-6 and TNFα increases underlined the neuroinflammation MWCNT-induced.•ROS overproduction MWCNT-driven caused neurotoxicity and neuroinflammation.•Despite the different shape, the harmful effe...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2017-12, Vol.56, p.121-128
Main Authors: Visalli, Giuseppa, Currò, Monica, Iannazzo, Daniela, Pistone, Alessandro, Pruiti Ciarello, Marianna, Acri, Giuseppe, Testagrossa, Barbara, Bertuccio, Maria Paola, Squeri, Raffaele, Di Pietro, Angela
Format: Article
Language:English
Subjects:
Blood-Brain Barrier
Brain
Carbon
Cell Line
Cell Survival - drug effects
Cells
Central nervous system
Cytotoxicity
Deoxyribonucleic acid
Differentiated SH-SY5Y cells
DNA
DNA Damage
Dose-Response Relationship, Drug
Enzyme-linked immunosorbent assay
Exposure
Gene Expression Regulation - drug effects
Genotoxicity
Humans
Hydrophobicity
Inflammation
Inflammation - genetics
Inflammation - metabolism
Interleukin 6
Interleukin-1beta - genetics
Interleukin-6 - genetics
Mitochondria - drug effects
Mitochondria - genetics
Mitochondrial DNA
Multi wall carbon nanotubes
Multi walled carbon nanotubes (MWCNTs)
Nanotechnology
Nanotubes
Nanotubes, Carbon - toxicity
Neurodegenerative diseases
Neuroinflammation
Neurological diseases
Neurotoxicity
Olfactory neurons
Organs
Oxidative damage
Raman spectra
Raman spectroscopy
Reactive oxygen species
Reactive Oxygen Species - metabolism
Time dependence
Time Factors
Toxicity
Transcription
Tumor Necrosis Factor-alpha - genetics
Tumor necrosis factor-α
Viability
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Summary:[Display omitted] •PMWCNT and fMWCNT triggered cyto- and geno-toxic effects in neuronal-like cells.•IL-1β, IL-6 and TNFα increases underlined the neuroinflammation MWCNT-induced.•ROS overproduction MWCNT-driven caused neurotoxicity and neuroinflammation.•Despite the different shape, the harmful effects of p-e f MWCNT were overlapped.•Effects of MWCNTs-cells interactions was highlighted by Raman spectrometry. Multi walled carbon nanotubes (MWCNTs) activate pathways involved in cytotoxicity, genotoxicity and inflammation. Inhaled MWCNTs are translocated to extra pulmonary organs and their hydrophobicity allows them to cross the blood–brain barrier (BBB). Further exposure of central nervous system (CNS) occurs via olfactory neurons. Using differentiated SH-SY5Y, we studied the neurotoxicity and neuroinflammation of pristine and functionalised MWCNTs. ROS overproduction was dose- and time-dependent (P
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2017.09.005