Vitamin D inadequacy in women treated for osteoporosis

Recently, [Holick MF] et al (2005) reported the results of a large North American study that assessed the vitamin D status of postmenopausal women receiving therapy to treat or prevent osteoporosis. In their study, 52% of 1536 women had inadequate [25(OH)D] levels (< 30 ng/mL), and 36 and 18% had...

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Bibliographic Details
Published in:Postgraduate medicine 2005-08, Vol.118 (2), p.17
Main Author: Mary P. GillamBy J. Larry Jameson
Format: Article
Language:English
Subjects:
Osteoporosis
Online Access:Get full text
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Summary:Recently, [Holick MF] et al (2005) reported the results of a large North American study that assessed the vitamin D status of postmenopausal women receiving therapy to treat or prevent osteoporosis. In their study, 52% of 1536 women had inadequate [25(OH)D] levels (< 30 ng/mL), and 36 and 18% had levels less than 25 and 20 ng/mL, respectively. Risk factors associated with vitamin D inadequacy included the following: BMI > 30 kg/m2, lack of exercise, lack of physician counseling regarding the importance of vitamin D, vitamin D supplementation less than 400 IU daily, and education level below grade 12. A subgroup analysis of 1246 subjects who had been on chronic (> /=1 year) therapy for osteoporosis revealed that 16.5% of these individuals had biochemical evidence of secondary hyperparathyroidism. Serum PTH values began to increase with [25(OH)D] levels less than 29.8 ng/mL.
ISSN:0032-5481
1941-9260
DOI:10.3810/pgm.2005.08.1825