pH-sensitive zwitterionic coating of gold nanocages improves tumor targeting and photothermal treatment efficacy

Stealth coating materials effectively extend a nanoparticle’s systemic circulation lifetime yet limit its cellular internalization, which promotes and prevents tumor targeting, respectively. Here, this contradiction was resolved by using an acutely pH-sensitive zwitterionic stealth ligand capable of...

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Bibliographic Details
Published in:Nano research 2018-06, Vol.11 (6), p.3193-3204
Main Authors: Piao, Ji-Gang, Gao, Feng, Li, Yunong, Yu, Lei, Liu, Dong, Tan, Zi-Bin, Xiong, Yujie, Yang, Lihua, You, Ye-Zi
Format: Article
Language:English
Subjects:
Animal models
Atomic/Molecular Structure and Spectra
Biomedicine
Biotechnology
Blood
Chemistry and Materials Science
Coating effects
Condensed Matter Physics
Gold
Internalization
Ligands
Materials Science
Nanoparticles
Nanotechnology
pH effects
Research Article
Tumors
Zwitterions
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Summary:Stealth coating materials effectively extend a nanoparticle’s systemic circulation lifetime yet limit its cellular internalization, which promotes and prevents tumor targeting, respectively. Here, this contradiction was resolved by using an acutely pH-sensitive zwitterionic stealth ligand capable of responding to small differences in extracellular pH between blood and tumors. Using a photothermal gold nanocage (AuNC) as a model nanotherapeutic, we found that stealth-AuNC nanoparticles showed both significantly enhanced cell uptake efficiency in acidic tumors and a markedly extended systemic circulation lifetime compared to its unaltered analogue. As a result, stealth-AuNC nanoparticles administered intravenously showed significantly enhanced accumulation within the tumor, leading to significantly improved photothermal therapeutic efficacy in mouse models. These results suggests that pH-sensitive zwitterionic ligands with sufficient sensitivity for responding to small differences in extracellular pH between blood and tumors are ideal stealth materials for simultaneously conferring both extended systemic circulation and enhanced cellular internalization, reducing the need for active targeting moieties.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-017-1736-7