Testicular zinc, copper and iron concentrations in male rats exposed to subacute and subchronic formaldehyde gas inhalation

The level of trace elements such as Zn, Cu and Fe in testicular tissue is an indication of the condition of the tissue as these elements take over important tasks. Zinc and copper are the prosthetic groups of several metalloenzymes including superoxide dismutase (SOD) which is an important antioxida...

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Bibliographic Details
Published in:Journal of trace elements in medicine and biology 2002-01, Vol.16 (2), p.119-122
Main Authors: Ozen, Oguz Aslan, Yaman, Mehmet, Sarsilmaz, Mustafa, Songur, Ahmet, Kus, Ilter
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Body Weight
Chemical and industrial products toxicology. Toxic occupational diseases
copper
Copper - analysis
Formaldehyde - administration & dosage
Formaldehyde - toxicity
inhalation
Inhalation Exposure
iron
Iron - analysis
Male
Medical sciences
Organ Size
Rats
Rats, Wistar
subacute
subchronic
Superoxide Dismutase - metabolism
Testis - chemistry
Testis - metabolism
Toxicology
Various organic compounds
zinc
Zinc - analysis
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Summary:The level of trace elements such as Zn, Cu and Fe in testicular tissue is an indication of the condition of the tissue as these elements take over important tasks. Zinc and copper are the prosthetic groups of several metalloenzymes including superoxide dismutase (SOD) which is an important antioxidant enzyme in the cellular protection from reactive oxygen species. If concentrations of these trace elements decrease significantly, SOD cannot detoxify harmful oxygen species. In this study, adult male rats (wistar-albino) were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (0; 12.2; 24.4 mg·L −1). Body and testis weights were recorded and compared with control groups. The metals described above were determined in rat testicular tissue by atomic absorption spectrometry by using wet ashing. We conclude that subacute or subchronic exposure to formaldehyde have caused growth retardation and altered levels of trace elements, including copper, zinc and iron, in testicular tissue, and may induce further oxidative damage on testicular tissue leading to spermatozoal abnormalities.
ISSN:0946-672X
1878-3252
DOI:10.1016/S0946-672X(02)80038-4