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Chronic DLL4 blockade induces vascular neoplasms
Arising from: J. Ridgway et al. Nature 444, 1083-1087 (2006)Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological...
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| Published in: | Nature (London) 2010-02, Vol.463 (7282), p.E6-E7 |
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| Main Authors: | , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c610t-e1367eb498904ab8aca2bd89aa14416ceaa45117e34e47b894d51c14398eae603 |
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| cites | cdi_FETCH-LOGICAL-c610t-e1367eb498904ab8aca2bd89aa14416ceaa45117e34e47b894d51c14398eae603 |
| container_end_page | E7 |
| container_issue | 7282 |
| container_start_page | E6 |
| container_title | Nature (London) |
| container_volume | 463 |
| creator | Yan, Minhong Callahan, Christopher A Beyer, Joseph C Allamneni, Krishna P Zhang, Gu Ridgway, John Brady Niessen, Kyle Plowman, Greg D |
| description | Arising from: J. Ridgway et al. Nature 444, 1083-1087 (2006)Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns. |
| doi_str_mv | 10.1038/nature08751 |
| format | article |
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Ridgway et al. Nature 444, 1083-1087 (2006)Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature08751</identifier><identifier>PMID: 20147986</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/92/609 ; 692/699/67/1059/602 ; 692/700/565/2194 ; Animals ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - pharmacology ; brief-communications-arising ; Care and treatment ; Cell cycle ; Chemical and Drug Induced Liver Injury - pathology ; Chemical and Drug Induced Liver Injury - physiopathology ; Endothelial Cells - drug effects ; Endothelial Cells - pathology ; Humanities and Social Sciences ; Humans ; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors ; Intracellular Signaling Peptides and Proteins - metabolism ; Macaca fascicularis ; Membrane Proteins - antagonists & inhibitors ; Membrane Proteins - metabolism ; Mice ; multidisciplinary ; Physiological aspects ; Proteins ; Rats ; Rattus ; Receptors, Notch - metabolism ; Risk factors ; Rodents ; Science ; Science (multidisciplinary) ; Signal Transduction ; Studies ; Tumors ; Vascular Neoplasms - chemically induced</subject><ispartof>Nature (London), 2010-02, Vol.463 (7282), p.E6-E7</ispartof><rights>Macmillan Publishers Limited. 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Ridgway et al. Nature 444, 1083-1087 (2006)Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>20147986</pmid><doi>10.1038/nature08751</doi><tpages>2</tpages></addata></record> |
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| source | Nature |
| subjects | 631/92/609 692/699/67/1059/602 692/700/565/2194 Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology brief-communications-arising Care and treatment Cell cycle Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - physiopathology Endothelial Cells - drug effects Endothelial Cells - pathology Humanities and Social Sciences Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Intracellular Signaling Peptides and Proteins - metabolism Macaca fascicularis Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Mice multidisciplinary Physiological aspects Proteins Rats Rattus Receptors, Notch - metabolism Risk factors Rodents Science Science (multidisciplinary) Signal Transduction Studies Tumors Vascular Neoplasms - chemically induced |
| title | Chronic DLL4 blockade induces vascular neoplasms |
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