Isolation of drug-resistant H5N1 virus

The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, whic...

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Bibliographic Details
Published in:Nature (London) 2005-10, Vol.437 (7062), p.1108-1108
Main Authors: Le, Q. Mai, Kiso, Maki, Someya, Kazuhiko, Sakai, Yuko T., Nguyen, T. Hien, Nguyen, Khan H. L., Pham, N. Dinh, Ngyen, Ha H., Yamada, Shinya, Muramoto, Yukiko, Horimoto, Taisuke, Takada, Ayato, Goto, Hideo, Suzuki, Takashi, Suzuki, Yasuo, Kawaoka, Yoshihiro
Format: Article
Language:English
Subjects:
Pandemics
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Summary:The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
ISSN:0028-0836
1476-4687
DOI:10.1038/4371108a