Palladium-catalyzed asymmetric dearomative alkenylation of indoles through a reductive-Heck reaction

A highly enantioselective intramolecular dearomatizing olefination of indoles has been developed through a Pd-catalyzed reductive Heck reaction. This protocol provides efficient access to optically active tetracyclic indolines bearing C2-alkenylated quaternary stereocenters in good yields with excel...

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Bibliographic Details
Published in:Organic chemistry frontiers an international journal of organic chemistry 2018-01, Vol.5 (11), p.1840-1843
Main Authors: Ren-Xiao, Liang, Yang, Run-Ze, Ren-Rong, Liu, Yi-Xia, Jia
Format: Article
Language:English
Subjects:
Enantiomers
Heterocyclic compounds
Indoles
Optical activity
Organic chemistry
Palladium
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Summary:A highly enantioselective intramolecular dearomatizing olefination of indoles has been developed through a Pd-catalyzed reductive Heck reaction. This protocol provides efficient access to optically active tetracyclic indolines bearing C2-alkenylated quaternary stereocenters in good yields with excellent enantioselectivities.
ISSN:2052-4110
2052-4110
DOI:10.1039/c8qo00205c