Possibility of Application of Extracellular Protease of the Micromycetе Aspergillus ochraceus VKM F-4104D for Determination of the Protein C Content in Human Blood Plasma

The protein C activator activity, determined in normal plasma by using A. ochraceus protease is comparable with the activity of a commercial protease analogue from the South American copperhead venom (Protac®). As in the case of Protac®, the A. ochraceus protease can be used for protein C determinat...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2018-04, Vol.12 (2), p.164-166
Main Authors: Osmolovskiy, A. A., Orekhova, A. V., Kreyer, V. G., Baranova, N. A., Egorov, N. S.
Format: Article
Language:English
Subjects:
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Medicinal Chemistry
Protein C
Proteinase
Proteins
Venom
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The protein C activator activity, determined in normal plasma by using A. ochraceus protease is comparable with the activity of a commercial protease analogue from the South American copperhead venom (Protac®). As in the case of Protac®, the A. ochraceus protease can be used for protein C determination in plasma with its reduced content. Comparison of the activator protein C activity of A. ochraceus protease and the commercial analogue showed some excess of the activator activity of the fungal preparation, which may be a promising substitute for the snake activator in diagnostical kits for determining the protein C content in clinical laboratories.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750818020099