Sulfated neo-clerodane diterpenoids and triterpenoid saponins from Sheareria nana S. Moore

Three novel neo-clerodane diterpenoids Sheareria A–C (1–3) together with three known triterpenoid saponins were isolated from the whole herb of Sheareria nana S. Moore. Their structures were established by spectroscopic and chemical method. This is the first natural sulfated neo-clerodane diterpenoi...

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Bibliographic Details
Published in:Fitoterapia 2018-01, Vol.124, p.12-16
Main Authors: Tang, Zhongyan, Shen, Junmei, Zhang, Feng, Liang, Jingyu, Xia, Zhengxiang
Format: Article
Language:English
Subjects:
Biological activity
Cancer
Chemotaxonomic
Chinese medicine
Cytotoxicity
Diterpenes
Herbs
Metabolites
Neo-clerodane diterpenoid
Phytochemicals
Saponins
Secondary metabolites
Sheareria nana
Sheareria nana S. Moore
Sulfated
Triterpenoid saponin
Tumor cell lines
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Summary:Three novel neo-clerodane diterpenoids Sheareria A–C (1–3) together with three known triterpenoid saponins were isolated from the whole herb of Sheareria nana S. Moore. Their structures were established by spectroscopic and chemical method. This is the first natural sulfated neo-clerodane diterpenoids. This is the first report of all these compounds from this plant. These neo-clerodane diterpenoids and triterpenoid saponins from S. nana S. Moore may be considered as chemotaxonomic markers for the genus. The compounds isolated were evaluated for their cytotoxic effects against three cancer cell lines, the test substances demonstrated selectivity toward the cancer cells. To date, this is the first report on the phytochemical and biological activity of secondary metabolites from S. nana S. Moore. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2017.10.002