Iron‐Catalyzed Synthesis of Amines and Thioethers Directly from Allylic Alcohols

A straightforward and efficient approach for the synthesis of allylic amines and thioethers has been developed by an iron‐catalyzed cross‐coupling reaction using diphosphite ligand. The reaction between allylic alcohols and amines/thiols gave allylic amine and thioester. The method is compatible wit...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2018-05, Vol.7 (5), p.875-878
Main Authors: Wang, Dan‐Yang, Peng, Xiao‐Min, Wang, Guang‐Zhu, Zhang, Ya‐Juan, Guo, Tao, Zhang, Pan‐Ke
Format: Article
Language:English
Subjects:
Alcohol
Alcohols
allylic alcohols
Amines
Chemical synthesis
diphosphite ligands
Functional groups
Iron
Organic chemistry
thioethers
Thiols
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Summary:A straightforward and efficient approach for the synthesis of allylic amines and thioethers has been developed by an iron‐catalyzed cross‐coupling reaction using diphosphite ligand. The reaction between allylic alcohols and amines/thiols gave allylic amine and thioester. The method is compatible with various functional groups, affording products with high yield and monoallylation selectivity. Proceed with an iron fist! A straightforward and efficient approach for the synthesis of allylic amines and thioethers has been developed by an iron‐catalyzed cross‐coupling reaction using a diphosphite ligand. The method is compatible with various functional groups, affording products with high yield and monoallylation selectivity.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201800083