Gold‐Catalyzed Polycyclization Toward Natural Products Synthesis

Over the last years, gold catalysis has gained considerable significance in organic synthesis, since it allows atom economy and synthetic efficiency for the transformation of relatively simple substrates into valuable, highly complex molecular architectures. The gold‐catalyzed polycyclization reacti...

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Bibliographic Details
Published in:Israel journal of chemistry 2018-05, Vol.58 (5), p.578-585
Main Authors: Toullec, Patrick Y., Michelet, Véronique
Format: Article
Language:English
Subjects:
Alkynes
Catalysis
Chemical reactions
Chemical synthesis
cycloisomerization reaction
domino process
Gold
Molecular chains
Natural products
Substrates
total synthesis
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Summary:Over the last years, gold catalysis has gained considerable significance in organic synthesis, since it allows atom economy and synthetic efficiency for the transformation of relatively simple substrates into valuable, highly complex molecular architectures. The gold‐catalyzed polycyclization reactions of alkynes and enynes have been particularly successful toward the synthesis of natural products. This review highlights the recent developments in polycyclization area according to the key gold‐catalyzed step.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.201800002