Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study

123I‐FP‐CIT and 18F‐FP‐CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head‐to‐head comparisons between 123I‐FP‐CIT and 18F‐FP‐CIT. Therefore, in this study, 123I‐FP‐CIT SPECT/CT was compared with 18F‐FP‐CI...

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Published in:Synapse (New York, N.Y.) N.Y.), 2018-07, Vol.72 (7), p.n/a
Main Authors: Lee, Inki, Kim, Jin Su, Park, Joon Yeun, Byun, Byung Hyun, Park, Su Yeon, Choi, Joon Ho, Moon, Hansol, Kim, Jung Young, Lee, Kyo Chul, Chi, Dae Yoon, Kim, Kyeong Min, Lim, Ilhan, Kang, Joo Hyun, Ahn, Soon Hyuk, Kim, Byung Il, Ha, Jeong Ho, Lim, Sang Moo
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Language:English
Subjects:
123I‐FP‐CIT
18F‐FP‐CIT
Computed tomography
Dopamine transporter
Movement disorders
Neostriatum
Neurodegenerative diseases
Parkinson's disease
positron emission tomography
Putamen
Single photon emission computed tomography
Tremor
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container_title Synapse (New York, N.Y.)
container_volume 72
creator Lee, Inki
Kim, Jin Su
Park, Joon Yeun
Byun, Byung Hyun
Park, Su Yeon
Choi, Joon Ho
Moon, Hansol
Kim, Jung Young
Lee, Kyo Chul
Chi, Dae Yoon
Kim, Kyeong Min
Lim, Ilhan
Kang, Joo Hyun
Ahn, Soon Hyuk
Kim, Byung Il
Ha, Jeong Ho
Lim, Sang Moo
description 123I‐FP‐CIT and 18F‐FP‐CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head‐to‐head comparisons between 123I‐FP‐CIT and 18F‐FP‐CIT. Therefore, in this study, 123I‐FP‐CIT SPECT/CT was compared with 18F‐FP‐CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT showed a positive correlation (r = .78, p 
doi_str_mv 10.1002/syn.22032
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However, to our knowledge, no studies to date have made head‐to‐head comparisons between 123I‐FP‐CIT and 18F‐FP‐CIT. Therefore, in this study, 123I‐FP‐CIT SPECT/CT was compared with 18F‐FP‐CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT showed a positive correlation (r = .78, p &lt; .01). However, the mean SBRs on 18F‐FP‐CIT PET/CT were higher than those on 123I‐FP‐CIT SPECT/CT (2.19 ± .87 and 1.22 ± .49, respectively; p &lt; .01). The PCRs in these two modalities were correlated with each other (r = .71, p &lt; .01). The mean PCRs on 18F‐FP‐CIT PET/CT were not significantly higher than those on 123I‐FP‐CIT SPECT/CT (1.31 ± .19 and 0.98 ± .06, respectively; p = .06). These preliminary results indicate that the uptake of both 123I‐FP‐CIT and 18F‐FP‐CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of 18F‐FP‐CIT PET/CT relative to 123I‐FP‐CIT SPECT/CT. The Specific binding ratio measured on 18F‐FP‐CIT PET and 123I‐FP‐CIT SPECT presented a significant positive linear correlation with each other. However, the mean SBRs on 18F‐FP‐CIT PET were significantly higherthan those on 123I‐FP‐CIT SPECT. The visual diagnostic performance for PD between 18F‐FP‐CIT PET and 123IFP‐CIT SPECT scans was not significantly different.</description><identifier>ISSN: 0887-4476</identifier><identifier>EISSN: 1098-2396</identifier><identifier>DOI: 10.1002/syn.22032</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>123I‐FP‐CIT ; 18F‐FP‐CIT ; Computed tomography ; Dopamine transporter ; Movement disorders ; Neostriatum ; Neurodegenerative diseases ; Parkinson's disease ; positron emission tomography ; Putamen ; Single photon emission computed tomography ; Tremor</subject><ispartof>Synapse (New York, N.Y.), 2018-07, Vol.72 (7), p.n/a</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2051-3597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Lee, Inki</creatorcontrib><creatorcontrib>Kim, Jin Su</creatorcontrib><creatorcontrib>Park, Joon Yeun</creatorcontrib><creatorcontrib>Byun, Byung Hyun</creatorcontrib><creatorcontrib>Park, Su Yeon</creatorcontrib><creatorcontrib>Choi, Joon Ho</creatorcontrib><creatorcontrib>Moon, Hansol</creatorcontrib><creatorcontrib>Kim, Jung Young</creatorcontrib><creatorcontrib>Lee, Kyo Chul</creatorcontrib><creatorcontrib>Chi, Dae Yoon</creatorcontrib><creatorcontrib>Kim, Kyeong Min</creatorcontrib><creatorcontrib>Lim, Ilhan</creatorcontrib><creatorcontrib>Kang, Joo Hyun</creatorcontrib><creatorcontrib>Ahn, Soon Hyuk</creatorcontrib><creatorcontrib>Kim, Byung Il</creatorcontrib><creatorcontrib>Ha, Jeong Ho</creatorcontrib><creatorcontrib>Lim, Sang Moo</creatorcontrib><title>Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study</title><title>Synapse (New York, N.Y.)</title><description>123I‐FP‐CIT and 18F‐FP‐CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head‐to‐head comparisons between 123I‐FP‐CIT and 18F‐FP‐CIT. Therefore, in this study, 123I‐FP‐CIT SPECT/CT was compared with 18F‐FP‐CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT showed a positive correlation (r = .78, p &lt; .01). However, the mean SBRs on 18F‐FP‐CIT PET/CT were higher than those on 123I‐FP‐CIT SPECT/CT (2.19 ± .87 and 1.22 ± .49, respectively; p &lt; .01). The PCRs in these two modalities were correlated with each other (r = .71, p &lt; .01). The mean PCRs on 18F‐FP‐CIT PET/CT were not significantly higher than those on 123I‐FP‐CIT SPECT/CT (1.31 ± .19 and 0.98 ± .06, respectively; p = .06). These preliminary results indicate that the uptake of both 123I‐FP‐CIT and 18F‐FP‐CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of 18F‐FP‐CIT PET/CT relative to 123I‐FP‐CIT SPECT/CT. The Specific binding ratio measured on 18F‐FP‐CIT PET and 123I‐FP‐CIT SPECT presented a significant positive linear correlation with each other. However, the mean SBRs on 18F‐FP‐CIT PET were significantly higherthan those on 123I‐FP‐CIT SPECT. The visual diagnostic performance for PD between 18F‐FP‐CIT PET and 123IFP‐CIT SPECT scans was not significantly different.</description><subject>123I‐FP‐CIT</subject><subject>18F‐FP‐CIT</subject><subject>Computed tomography</subject><subject>Dopamine transporter</subject><subject>Movement disorders</subject><subject>Neostriatum</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>positron emission tomography</subject><subject>Putamen</subject><subject>Single photon emission computed tomography</subject><subject>Tremor</subject><issn>0887-4476</issn><issn>1098-2396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpNUEtOwzAUtBBIlMKCG1hiwSrt8yeJww5VFCpVgERZsIqc2G1dWjvYqarsOAIH4HScBFNYsJn39N5oRjMInRMYEAA6DJ0dUAqMHqAegUIklBXZIeqBEHnCeZ4do5MQVgDACPAe-rzTUn29f7QuwjLuuHabRnoTnMVujokYx8f4McJoMsPSKkwom_y_zZ3HyjVyY6zGrZc2NM632mOzkQtjF9hY3MjWaNsGvDPtEj9K_2psdLgMWJmgZdBX-Bo3Xq9NVJG-w6Hdqu4UHc3lOuizv9lHz-Ob2egumT7cTkbX06QhMWkimOYAila0AkVEnVbAMiqzrMiqvGAVEZRXqdairmrCVJ5yUYi0EIpoKbKCsz66-NVtvHvb6tCWK7f1NlqWFHjOWZZCEVnDX9bOrHVXNj7m811JoPxpvozNl_vmy6eX-_3CvgEJI32o</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Lee, Inki</creator><creator>Kim, Jin Su</creator><creator>Park, Joon Yeun</creator><creator>Byun, Byung Hyun</creator><creator>Park, Su Yeon</creator><creator>Choi, Joon Ho</creator><creator>Moon, Hansol</creator><creator>Kim, Jung Young</creator><creator>Lee, Kyo Chul</creator><creator>Chi, Dae Yoon</creator><creator>Kim, Kyeong Min</creator><creator>Lim, Ilhan</creator><creator>Kang, Joo Hyun</creator><creator>Ahn, Soon Hyuk</creator><creator>Kim, Byung Il</creator><creator>Ha, Jeong Ho</creator><creator>Lim, Sang Moo</creator><general>Wiley Subscription Services, Inc</general><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-2051-3597</orcidid></search><sort><creationdate>201807</creationdate><title>Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study</title><author>Lee, Inki ; Kim, Jin Su ; Park, Joon Yeun ; Byun, Byung Hyun ; Park, Su Yeon ; Choi, Joon Ho ; Moon, Hansol ; Kim, Jung Young ; Lee, Kyo Chul ; Chi, Dae Yoon ; Kim, Kyeong Min ; Lim, Ilhan ; Kang, Joo Hyun ; Ahn, Soon Hyuk ; Kim, Byung Il ; Ha, Jeong Ho ; Lim, Sang Moo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1032-83e400d2b2b0d18c5b0362a6696b793b1824b5ee8cbc13d754898598d1ea86943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>123I‐FP‐CIT</topic><topic>18F‐FP‐CIT</topic><topic>Computed tomography</topic><topic>Dopamine transporter</topic><topic>Movement disorders</topic><topic>Neostriatum</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>positron emission tomography</topic><topic>Putamen</topic><topic>Single photon emission computed tomography</topic><topic>Tremor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Inki</creatorcontrib><creatorcontrib>Kim, Jin Su</creatorcontrib><creatorcontrib>Park, Joon Yeun</creatorcontrib><creatorcontrib>Byun, Byung Hyun</creatorcontrib><creatorcontrib>Park, Su Yeon</creatorcontrib><creatorcontrib>Choi, Joon Ho</creatorcontrib><creatorcontrib>Moon, Hansol</creatorcontrib><creatorcontrib>Kim, Jung Young</creatorcontrib><creatorcontrib>Lee, Kyo Chul</creatorcontrib><creatorcontrib>Chi, Dae Yoon</creatorcontrib><creatorcontrib>Kim, Kyeong Min</creatorcontrib><creatorcontrib>Lim, Ilhan</creatorcontrib><creatorcontrib>Kang, Joo Hyun</creatorcontrib><creatorcontrib>Ahn, Soon Hyuk</creatorcontrib><creatorcontrib>Kim, Byung Il</creatorcontrib><creatorcontrib>Ha, Jeong Ho</creatorcontrib><creatorcontrib>Lim, Sang Moo</creatorcontrib><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Synapse (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Inki</au><au>Kim, Jin Su</au><au>Park, Joon Yeun</au><au>Byun, Byung Hyun</au><au>Park, Su Yeon</au><au>Choi, Joon Ho</au><au>Moon, Hansol</au><au>Kim, Jung Young</au><au>Lee, Kyo Chul</au><au>Chi, Dae Yoon</au><au>Kim, Kyeong Min</au><au>Lim, Ilhan</au><au>Kang, Joo Hyun</au><au>Ahn, Soon Hyuk</au><au>Kim, Byung Il</au><au>Ha, Jeong Ho</au><au>Lim, Sang Moo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study</atitle><jtitle>Synapse (New York, N.Y.)</jtitle><date>2018-07</date><risdate>2018</risdate><volume>72</volume><issue>7</issue><epage>n/a</epage><issn>0887-4476</issn><eissn>1098-2396</eissn><abstract>123I‐FP‐CIT and 18F‐FP‐CIT are radiotracers which are widely used to diagnose Parkinson's disease (PD). However, to our knowledge, no studies to date have made head‐to‐head comparisons between 123I‐FP‐CIT and 18F‐FP‐CIT. Therefore, in this study, 123I‐FP‐CIT SPECT/CT was compared with 18F‐FP‐CIT PET/CT in the same cohort of subjects. Patients with PD and essential tremor (ET) underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual and semiquantitative analyses were conducted. The specific binding ratio (SBR) and putamen to caudate ratio (PCR) were compared between subjects who underwent 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT. Visual analysis showed that the striatal uptake of both radiotracers was decreased in the PD group, whereas striatal uptake was intact in the ET group. The SBR between 123I‐FP‐CIT SPECT/CT and 18F‐FP‐CIT PET/CT showed a positive correlation (r = .78, p &lt; .01). However, the mean SBRs on 18F‐FP‐CIT PET/CT were higher than those on 123I‐FP‐CIT SPECT/CT (2.19 ± .87 and 1.22 ± .49, respectively; p &lt; .01). The PCRs in these two modalities were correlated with each other (r = .71, p &lt; .01). The mean PCRs on 18F‐FP‐CIT PET/CT were not significantly higher than those on 123I‐FP‐CIT SPECT/CT (1.31 ± .19 and 0.98 ± .06, respectively; p = .06). These preliminary results indicate that the uptake of both 123I‐FP‐CIT and 18F‐FP‐CIT was decreased in the PD group when compared with the ET controls. Visual analyses using both methods did not affect the diagnostic accuracy in this study. However, semiquantitative analysis indicated a better contrast of 18F‐FP‐CIT PET/CT relative to 123I‐FP‐CIT SPECT/CT. The Specific binding ratio measured on 18F‐FP‐CIT PET and 123I‐FP‐CIT SPECT presented a significant positive linear correlation with each other. However, the mean SBRs on 18F‐FP‐CIT PET were significantly higherthan those on 123I‐FP‐CIT SPECT. The visual diagnostic performance for PD between 18F‐FP‐CIT PET and 123IFP‐CIT SPECT scans was not significantly different.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/syn.22032</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2051-3597</orcidid><oa>free_for_read</oa></addata></record>
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source Wiley-Blackwell Read & Publish Collection
subjects 123I‐FP‐CIT
18F‐FP‐CIT
Computed tomography
Dopamine transporter
Movement disorders
Neostriatum
Neurodegenerative diseases
Parkinson's disease
positron emission tomography
Putamen
Single photon emission computed tomography
Tremor
title Head‐to‐head comparison of 18F‐FP‐CIT and 123I‐FP‐CIT for dopamine transporter imaging in patients with Parkinson's disease: A preliminary study
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