Stability of 17¿-methyltestosterone in fish feed

The synthetic steroid 17α-methyltestosterone (MT) is used as a feed additive to produce predominately male populations of tilapia (Oreochromis sp.). The legal use of MT by the U.S. tilapia industry requires an approved New Animal Drug Application (NADA) from the U.S. Food and Drug Administration (FD...

Full description

Saved in:
Bibliographic Details
Published in:Aquaculture 2007-10, Vol.271 (1-4), p.523
Main Authors: Barry, Terence P, Marwah, Ashok, Marwah, Padma
Format: Article
Language:English
Subjects:
Animal reproduction
Aquaculture
FDA approval
Feeds
Steroids
Studies
Tilapia
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthetic steroid 17α-methyltestosterone (MT) is used as a feed additive to produce predominately male populations of tilapia (Oreochromis sp.). The legal use of MT by the U.S. tilapia industry requires an approved New Animal Drug Application (NADA) from the U.S. Food and Drug Administration (FDA). The present study was conducted to satisfy the remaining FDA data requirements in the area of product chemistry. The results indicated that (1) MT-treated feed is homogenously mixed during the manufacturing and bagging process, (2) MT remains uniformly distributed throughout the feed during prolonged storage at room temperature, and (3) MT concentrations in fish feed are stable for at least several months when feed is stored at 4 ...C or lower, but decline linearly with time at higher temperatures. The half-life of MT (i.e., the time required for the MT concentration to fall from 60 mg/kg to 30 mg/kg) was 1.1 and 4.8 months for feed stored at 40 ...C and 22 ...C, respectively. (ProQuest: ... denotes formulae/symbols omitted.)
ISSN:0044-8486
1873-5622