Construction of dual-functional polymer nanomaterials with near-infrared fluorescence imaging and polymer prodrug by RAFT-mediated aqueous dispersion polymerization

The performance of functional polymer nanomaterials is a vigorously discussed topic in polymer science. We devoted ourselves to investigating polymer nanomaterials based on near-infrared (NIR) fluorescence imaging and polymer prodrug in this study. Aza-boron dipyrromethene (BODIPY) is an important o...

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Bibliographic Details
Published in:Nanoscale 2018-06, Vol.10 (21), p.10277-10287
Main Authors: Tian, Chun, Niu, Jinyun, Wei, Xuerui, Xu, Yujie, Zhang, Lifen, Cheng, Zhenping, Zhu, Xiulin
Format: Article
Language:English
Subjects:
Biocompatibility
Boron
Chain transfer
Chemical synthesis
Copolymerization
Dispersion
Dyes
Fluorescence
In vivo methods and tests
Infrared imaging
Microscopy
Monomers
Morphology
Nanomaterials
Nanoparticles
Photon correlation spectroscopy
Polymerization
Polymers
Scanning microscopy
Signal processing
Toxicity
Transmission electron microscopy
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Summary:The performance of functional polymer nanomaterials is a vigorously discussed topic in polymer science. We devoted ourselves to investigating polymer nanomaterials based on near-infrared (NIR) fluorescence imaging and polymer prodrug in this study. Aza-boron dipyrromethene (BODIPY) is an important organic dye, having characteristics such as environmental resistance, light resistance, high molar extinction coefficient, and fluorescence quantum yield. We incorporated it into our target monomer, which can be polymerized without changing its parent structure in a polar solvent and copolymerized with water-soluble monomer to improve the solubility of the dye in an aqueous solution. At the same time, the hydrophobic drug camptothecin (CPT) was designed as a prodrug monomer, and the polymeric nanoparticles (NPs) with NIR fluorescence imaging and prodrug were synthesized in situ in reversible addition-fragmentation chain transfer (RAFT)-mediated aqueous dispersion polymerization. The dynamic light scattering (DLS) and transmission electron microscopy (TEM) revealed the final uniform size of the dual-functional polymeric NPs morphology. The dual-functional polymeric NPs had a strong absorption and emission signal in the NIR region (>650 nm) based on the fluorescence tests. In consideration of the long-term biological toxicity, confocal laser scanning microscopy (CLSM) results indicated that the dual-functional NPs with controlled drug content exhibited effective capability of killing HeLa cells. In addition, in vivo imaging of the dual-functional NPs was observed in real time, and the fluorescent signals clearly demonstrated the dynamic process of prodrug transfer.
ISSN:2040-3364
2040-3372
DOI:10.1039/c8nr00930a