Formulation of Modified Release Pellets of Montelukast Sodium

• Published in: Research journal of pharmacy and technology 2018, Vol.11 (1), p.31-37
• Main Authors: Diggikar, Susmit S., Nandgude, Tanaji D., Poddar, Sushilkumar S.
• Format: Article
• Language: English
• Subjects: Arthritis; Asthma; Bioavailability; Cellulose; Circadian rhythm; Computer simulation; Disease; Drug delivery systems; Drug dosages; Pharmaceutical sciences; Pharmacy; Sodium; Ulcers
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2018.00006.9

The increase in the coating level increased the lag time sufficiently that might release the drug during the early morning hours. [...]a modified release pellets dosage form to prevent the early morning asthma attacks and exacerbations was developed successfully. Most persons experience the worsening of their asthma during the night, and many experience asthma only at night 12. [...]successful asthma management must address the major features of the disease-airway inflammation and hyper reactivity, compromised pulmonary function, and nocturnal exacerbations. [...]the administration of a drug formulated in such a delivery system, i.e. taken at bedtime with a programmed start of drug release in early morning hours, could offer a more effective therapy than a typical controlled release drug delivery system, provided that the most appropriate drugs are administrated.14 Montelukast has been studied more extensively for dosing-time differences in efficacy and safety than zarfirlukast and pranlukast, which are typically dosed twice daily at equal intervals; thus, this section focuses exclusively on montelukast. [...]delayed release in burst form in pH6.8 was obtained with the coated pellets. [...]this type of modified release may be used for the treatment of the asthma attacks and exacerbations observed during the early morning hours.