Formulation and evaluation of vilazodone sublingual tablets by using lyophilization technique

[...]the bioavailability studies of the prepared tablets were performed by sublingual administration to rabbits. Because of its partial agonist activity for serotonin-1A, vilazodone helps to reduce anxiety. [...]the lyophilized solid dispersion VZD-PXM 407 Lyo1:5 showed the maximum solubility and di...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018, Vol.11 (1), p.267-274
Main Authors: Panda, K. C, Reddy, A. V, Panda, N., Shamim, MD, Habibuddin, M., Jayaveera, K.N
Format: Article
Language:English
Subjects:
Antidepressants
Bioavailability
Drug delivery systems
FDA approval
Fourier transforms
Pharmaceuticals
Potassium
Serotonin
Spectrum analysis
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Summary:[...]the bioavailability studies of the prepared tablets were performed by sublingual administration to rabbits. Because of its partial agonist activity for serotonin-1A, vilazodone helps to reduce anxiety. [...]the lyophilized solid dispersion VZD-PXM 407 Lyo1:5 showed the maximum solubility and dissolution rate was selected for preparation of sublingual tablets. [...]this dosage form could be a useful alternative to the commercial tablet with regards to its improved patient compliance, rapid onset of action, and increase in bioavailability.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00050.1