Haplotype and Allelic Variations at Dopamine Receptor Gene (DRD2) among six Austro-Asiatic Speaking Tribal Groups of Central India

[...]haplotype investigations can distinguish remarkable chromosomal sections prone to harbor illness inclining qualities. The frequency and presence of the ancestral allele in a population will give the information whether population under study have African ancestry. [...]in the present study, thr...

Full description

Saved in:
Bibliographic Details
Published in:Research journal of pharmacy and technology 2018, Vol.11 (1), p.54-60
Main Authors: Sinha, Moumita, Temunkar, Pankaj, Mitra, Mitashree, Rao, I Arjun
Format: Article
Language:English
Subjects:
Chromosomes
Dopamine
Genetics
Haplotypes
Integrated software
Multiculturalism & pluralism
Population
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[...]haplotype investigations can distinguish remarkable chromosomal sections prone to harbor illness inclining qualities. The frequency and presence of the ancestral allele in a population will give the information whether population under study have African ancestry. [...]in the present study, three polymorphic sites TaqIA (rs1800497); TaqIB (rs1079597) and TaqID (rs1800498) of DRD2 locus has been used to determine the frequency and distribution of ancestral alleles and haplotype variations among the six Austro-Asiatic speaking tribal population groups with distinct ethnic and linguistic backgrounds, chosen from Madhya Pradesh and Chhattisgarh state of Central India to infer the indigenous origin of Austro-Asiatic speaking tribes of central region (Fig1.). At present, no published database is available for B2, D2 and A1 allele in Austro-Asiatic speaking tribes except Ho and Munda for comparison. [...]it can be said that Indo-European, Dravidian and Tibeto-Burman speaking tribes of India has the frequency of ancestral alleles B2, D2 and A1 in significant frequencies and in concordance with the African values. In India, various linguistic and ethnic populations exhibit low significant LD. [...]present findings on LD values in six Austro-Asiatic speaking tribes fall within the range of Indian values.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00011.2