Phytochemical Screening and In vitro Cytotoxicity Studies of Mussaenda frondosa Linn Leaves

Ages since early human existence, many natural materials by instinct, induction or trial and error got in use for combating human ailments. [...]traditional systems of medicine such as Ayurveda, Siddha, Unani, Homeopathy etc, depend heavily on natural products. HepG2 (Human liver hepatocellular carc...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2017-12, Vol.10 (12), p.4227-4230
Main Authors: Pappachen, Leena K., Sreelakshmi, K. S.
Format: Article
Language:English
Subjects:
Asthma
Cancer
Chromatography
Cytotoxicity
Diuretics
Flavonoids
Fruits
Herbal medicine
Medicine
Methods
Pharmacy
Phytochemicals
Studies
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Summary:Ages since early human existence, many natural materials by instinct, induction or trial and error got in use for combating human ailments. [...]traditional systems of medicine such as Ayurveda, Siddha, Unani, Homeopathy etc, depend heavily on natural products. HepG2 (Human liver hepatocellular carcinoma cell line), was cultured in DMEM supplemented with 10% inactivated Fetal Bovine Serum (FBS), penicillin (100 IU/ml), streptomycin (100 pg/ml) and amphotericin B (5 pg/ml) in an humidified atmosphere of 5% CO2 at 37°C until confluent. The phytochemical tests revealed that the leaves of Mussaenda frondosa Linn possess presence of various secondary metabolites like flavonoids, glycosides, saponins, tannins, phenolic compounds as shown in Table-2. Since the methanolic extract shows higher concentration of chemical constituents it was subjected for the further study. [...]the present findings provide scientific evidence that methanolic extract and the isolated flavonoid fraction of Mussaenda frondosa Linn can be used as a potent anticancer agent.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2017.00774.0