Genetic polymorphisms of IL-17A rs2275913, rs3748067 and IL-17F rs763780 in gastric cancer risk: evidence from 8124 cases and 9873 controls

• Published in: Molecular biology reports 2018-10, Vol.45 (5), p.1421-1444
• Main Authors: Elshazli, Rami M., Salman, Doaa O., Kamel, Maha M., Toraih, Eman A., Fawzy, Manal S.
• Format: Article
• Language: English
• Subjects: Animal Anatomy; Animal Biochemistry; Asian Continental Ancestry Group - genetics; Biomedical and Life Sciences; Carcinogenesis; Case-Control Studies; Data processing; Female; Gastric cancer; Gene Frequency; Gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease; Histology; Humans; Interleukin 17; Interleukin-17 - genetics; Interleukin-17 - metabolism; Life Sciences; Male; Meta-analysis; Morphology; Odds Ratio; Polymorphism; Polymorphism, Single Nucleotide; Review; Risk Factors; Single-nucleotide polymorphism; Stomach Neoplasms - genetics; Structure-function relationships
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-018-4202-z

Interleukin-17 (IL-17) is a critical cytokine involved in inflammation-associated cancers. Single nucleotide polymorphisms (SNPs) might promote carcinogenesis. In this current meta-analysis, we investigated the association of IL-17A and IL-17F gene polymorphisms with gastric cancer (GC) risk. Eligible genetic association studies were retrieved from PubMed, Web of Science and Scopus database sources. Two reviewers independently assessed methodological quality and extracted data from eligible articles. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Quantitative data synthesis was conducted using comprehensive meta-analysis v2. Subgroup analysis and heterogeneity analysis were performed. Begg’s funnel plot and Egger’s regression tests were used to judge publication bias. In silico data analysis was executed to analyze the functional and structural impact of the SNPs. A total of 21 case-control studies for rs2275913 c.-197G > A (7660 patients and 9409 controls), 9 studies for rs3748067 c.*1249C > T (3378 patients and 4120 controls), and 14 studies for rs763780 c.482A > G (4481 patients and 5354 controls) were included. The pooled estimate revealed an association between IL-17A rs2275913 polymorphism and the risk of GC under all genetic models (A vs. G, OR 1.187, 95% CI 1.086–1.297, P