Recent Advances in the Construction of C–N Bonds Through Coupling Reactions between Carbon Radicals and Nitrogen Radicals

C−N bonds are widely found in natural products, medicinal molecules and multifunctional materials. In recent years, the construction of C−N bonds through a radical coupling reaction between carbon‐centered radicals with nitrogen‐centered radicals has emerged as a frontier area in organic chemistry....

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2018-06, Vol.360 (11), p.2076-2086
Main Authors: Luo, Junfei, Wei, Wen‐Ting
Format: Article
Language:English
Subjects:
Carbon
carbon-centered radicals
Chemical reactions
Coupling (molecular)
C−N bonds
Molecular chains
Multifunctional materials
Natural products
Nitrogen
nitrogen-centered radicals
Organic chemistry
radical coupling reactions
Radicals
Reaction mechanisms
Substrates
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Summary:C−N bonds are widely found in natural products, medicinal molecules and multifunctional materials. In recent years, the construction of C−N bonds through a radical coupling reaction between carbon‐centered radicals with nitrogen‐centered radicals has emerged as a frontier area in organic chemistry. This review summarizes the recent advances (especially those after 2012) in radical coupling reactions that facilitate the formation of C−N bonds. The main achievements on this area are presented according to the pattern of the nitrogen‐centered radicals generated. Selected examples of substrates are listed and special attention is paid to the reaction mechanisms. Moreover, a personal outlook is described at the end.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800205