Anatolian Propolis Prevents Oxalate Kidney Stones: Dramatic Reduction of Crystal Deposition in Ethylene-Glycol-Induced Rat Mode Fehmi Narter, Ayça Diren, Alper Kafkaslı, Allison P. Eronat, M. Fatih Seyhan, Hülya Yılmaz-Aydoğan, Sukran Sarıkaya, Seda Damla Hatipoğlu

• Published in: Records of natural products 2018-01, Vol.12 (5), p.445
• Main Authors: Narter, Fehmi, Diren, Ayça, Alper Kafkaslı, Eronat, Allison P, Seyhan, M Fatih, Yılmaz-Aydoğan, Hülya, Sarıkaya, Sukran, Seda Damla Hatipoğlu, Sarıca, Kemal, Ozturk, Oguz
• Format: Article
• Language: English
• ISSN: 1307-6167
• DOI: 10.25135/rnp.48.17.11.075

One of the many properties of propolis, a gift of nature, is that it is a potent antioxidant agent, which has been shown to be a miracle-worker in many different diseases. In this study, its possible protective and reversing effects against hiperoxaluria was investigated in a rat model in comparison with verapamil. In all 5 groups (Total n=76), aside from the control, hiperoxaluria was induced with continuous ethylene glycol (EG) administration. The others received EG only, 50 mg/kg propolis, 100 mg/kg propolis and 1mg/kg verapamil. To estimate the antioxidant/oxidant status in the tissue and serum samples, catalase (CAT), superoxide dismutase (SOD), total glutathione (GSH), nitric oxide (NO), malonyl dialdehyde (MDA) and total anti-oxidant capacity (T-AOC) were measured after 7 and 28 days. In the early phase, serum T-AOC levels were significantly elevated in the EG+P100 (p=0.0062) compared to the control, while in the late phase, it was elevated in the EG+P50 (p=0.037) and EG+V (p=0.009) compared to the EG only group. Propolis administration was observed to dramatically decrease crystal deposition (p