Leptin linked to rewiring in brain's feeding circuit

By means of immunohisto-chemistry and electron microscopy, the authors determined that, compared with wild-type mice, leptin-deficient (ob/ob) mice had a significantly greater number of excitatory synapses onto NPY neurons and a significantly greater number of inhibitory synapses onto POMC neurons....

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Bibliographic Details
Published in:Canadian Medical Association journal (CMAJ) 2004-06, Vol.170 (12), p.1787
Main Author: Busko, Marlene
Format: Article
Language:English
Subjects:
Causes
Hormones
Leptin
Neurons
Obesity
Online Access:Get full text
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Summary:By means of immunohisto-chemistry and electron microscopy, the authors determined that, compared with wild-type mice, leptin-deficient (ob/ob) mice had a significantly greater number of excitatory synapses onto NPY neurons and a significantly greater number of inhibitory synapses onto POMC neurons. Differences in the number of excitatory (red) and inhibitory (blue) synaptic inputs onto NPY (yellow) and POMC (green) neurons in wild-type mice, ob/ob mice and ob/ob mice given leptin. Reprinted, with permission from Science 2004;304:114.
ISSN:0820-3946
1488-2329
DOI:10.1503/cmaj.1040782