Long-term Administration of L-Arginine Improves Nitric Oxide Release From Kidney in Deoxycorticosterone Acetate-Salt Hypertensive Rats

To examine the effects of L-arginine (L-Arg) on endothelial function, we administered 0.5 g/L L-Arg in drinking water to deoxycorticosterone acetate (DOCA)-salt rats for 8 weeks and then measured nitric oxide (NO) release from isolated kidneys using a newly developed real-time chemiluminescence meth...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-06, Vol.23 (6, Part 1), p.752-756
Main Authors: Hayakawa, Hiroshi, Hirata, Yasunobu, Suzuki, Etsu, Kimura, Kenjiro, Kikuchi, Kazuya, Nagano, Tetsuo, Hirobe, Masaaki, Omata, Masao
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Arginine - administration & dosage
Arginine - pharmacology
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - drug effects
Cardiology. Vascular system
Desoxycorticosterone
Experimental diseases
Hypertension - chemically induced
Hypertension - metabolism
Hypertension - pathology
In Vitro Techniques
Kidney - metabolism
Kidney - pathology
Medical sciences
Nitric Oxide - metabolism
Perfusion
Pressure
Rats
Rats, Wistar
Sodium Chloride
Time Factors
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Summary:To examine the effects of L-arginine (L-Arg) on endothelial function, we administered 0.5 g/L L-Arg in drinking water to deoxycorticosterone acetate (DOCA)-salt rats for 8 weeks and then measured nitric oxide (NO) release from isolated kidneys using a newly developed real-time chemiluminescence method. Renal pathology was also analyzed. Acetylcholine caused much smaller declines in renal perfusion pressure (10 mol/L acetylcholine−24±2% [SEM] versus −50±2%, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.23.6.752