Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep

ABSTRACT—Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure i...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2002-11, Vol.40 (5), p.729-734
Main Authors: Dodic, Miodrag, Abouantoun, Tamara, O’Connor, Anne, Wintour, E Marelyn, Moritz, Karen M
Format: Article
Language:English
Subjects:
Angiotensinogen - genetics
Angiotensinogen - metabolism
Angiotensins - metabolism
Animals
Blood Pressure - drug effects
Brain Chemistry
Dexamethasone - administration & dosage
Dexamethasone - pharmacology
Drug Administration Routes
Female
Fetal Weight - drug effects
Fetus - drug effects
Gene Expression - drug effects
Glucocorticoids - pharmacology
Hormone Replacement Therapy
Hypertension - chemically induced
Hypertension - physiopathology
Hypothalamus - chemistry
Hypothalamus - drug effects
Hypothalamus - embryology
Male
Medulla Oblongata - chemistry
Medulla Oblongata - drug effects
Medulla Oblongata - embryology
Models, Animal
Organ Size - drug effects
Pregnancy
Prenatal exposure
Prenatal Exposure Delayed Effects
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - genetics
Receptors, Angiotensin - metabolism
RNA, Messenger - analysis
RNA, Messenger - metabolism
Sex Factors
Sheep
Testosterone - administration & dosage
Testosterone - blood
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Summary:ABSTRACT—Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure in male and female offspring and whether hypertension in males was modulated by testosterone status, and (2) altered gene expression for angiotensinogen and angiotensin type 1 (AT1) receptors in the brain in late gestation and in the adult. Basal mean arterial pressure (MAP) at 2 years of age was significantly higher in wethers exposed to prenatal dexamethasone (group D; 106±5 mm Hg, n=9) compared with the control group (group S; 91±3 mm Hg, n=8;P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000036455.62159.7E