Interaction of (alpha)1-Na,K-ATPase and Na,K,2C1-cotransporter genes in human essential hypertension

Essential hypertension is a common disease the genetic determinants of which have been difficult to unravel because of its clinical heterogeneity and complex, multifactorial, polygenic etiology. Based on our observations that alpha(1)-Na,K-ATPase (ATP1A1) and renal-specific, bumetanide-sensitive Na,...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-08, Vol.38 (2), p.204
Main Authors: Glorioso, Nicola, Filigheddu, Fabiana, Troffa, Chiara, Soro, Aldo
Format: Article
Language:English
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Summary:Essential hypertension is a common disease the genetic determinants of which have been difficult to unravel because of its clinical heterogeneity and complex, multifactorial, polygenic etiology. Based on our observations that alpha(1)-Na,K-ATPase (ATP1A1) and renal-specific, bumetanide-sensitive Na,K,2Cl-cotransporter (NKCC2) genes interactively increase susceptibility to hypertension in the Dahl salt-sensitive hypertensive (Dahl S) rat model, we investigated whether parallel molecular genetic mechanisms might exist in human essential hypertension in a relatively genetic homogeneous cohort in northern Sardinia. Putative ATP1A1-NKCC2 gene interaction was tested by comparing hypertensive patients (blood pressure [BP] >165/95 mm Hg) with normotensive controls age >60 years with BP
ISSN:0194-911X
1524-4563