Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity

Methanolic extracts of seven herbs ( Acorus calamus, Acorus gramineus, Bupleurm facaltum, Dioscorea batatas, Epimedium koreanum, Poria cocos and Zizyphi jujuba) used in traditional Korean medicine for improvement of memory and cognition in old age were tested for cholinesterase inhibitory properties...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2004-09, Vol.11 (6), p.544-548
Main Authors: Oh, M.H., Houghton, P.J., Whang, W.K., Cho, J.H.
Format: Article
Language:English
Subjects:
Acetylcholinesterase - drug effects
Acetylcholinesterase - metabolism
Acorus
Alzheimer Disease - prevention & control
Anti-acetylcholinesterase
Bupleurum
Care and treatment
Cholinesterase Inhibitors - administration & dosage
Cholinesterase Inhibitors - pharmacology
Cholinesterase Inhibitors - therapeutic use
Cholinesterases
Cognition - drug effects
Dioscorea
Dose-Response Relationship, Drug
Epimedium
Erythrocytes - enzymology
Hoelen
Humans
Inhibitory Concentration 50
Korea
Medical research
Medicine, Botanic
Medicine, Experimental
Medicine, Herbal
Medicine, Traditional
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Oils - administration & dosage
Plant Oils - pharmacology
Plant Oils - therapeutic use
Plant Roots
Plants, Medicinal
Screening
Zizyphus
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Summary:Methanolic extracts of seven herbs ( Acorus calamus, Acorus gramineus, Bupleurm facaltum, Dioscorea batatas, Epimedium koreanum, Poria cocos and Zizyphi jujuba) used in traditional Korean medicine for improvement of memory and cognition in old age were tested for cholinesterase inhibitory properties using the Ellman colorimetric method. Significant inhibition of the enzyme at 200 μg/ml was observed for extracts from A. calamus and E. koreanum. The possible bases for the reputation of these and the other herbs tested are discussed in the light of previous investigations into their chemistry and biological activity.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2004.03.001