Triterpenoid cynarasaponins from Cynara cardunculus L. reduce chemically induced mutagenesis in vitro

Saponins, steroid or triterpene glycosides, are known to have a broad spectrum of biological and pharmacological activities. Three different triterpenoid saponins, marked here as 1s, 2s and 3s, from involucral bracts of Cynara cardunculus L. were isolated and their antimutagenic effect was assessed....

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2004-11, Vol.11 (7-8), p.673-678
Main Authors: Križková, L., Mučaji, P., Nagy, M., Krajčovič, J.
Format: Article
Language:English
Subjects:
Acridine orange
Acridine Orange - toxicity
Animals
Antimutagenic Agents - isolation & purification
Antimutagenic Agents - pharmacology
Antimutagenicity
Chemical mutagenesis
Cynara - chemistry
Cynarasaponins
Euglena gracilis
Euglena gracilis - drug effects
Euglena gracilis - genetics
Medicinal plants
Molecular Structure
Ofloxacin
Ofloxacin - antagonists & inhibitors
Ofloxacin - toxicity
Saponins
Saponins - isolation & purification
Saponins - pharmacology
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:Saponins, steroid or triterpene glycosides, are known to have a broad spectrum of biological and pharmacological activities. Three different triterpenoid saponins, marked here as 1s, 2s and 3s, from involucral bracts of Cynara cardunculus L. were isolated and their antimutagenic effect was assessed. Using spectrophotometric method it was shown that all three substances, 1s, 2s and 3s, possess very good absorptive capability. The antimutagenic effect of these substances was estimated against acridine orange (AO)- and ofloxacin-induced damage of chloroplast DNA in Euglena gracilis assay. These cynarasaponins were experimentally confirmed to exhibit different, statistically significant activity in reducing damage of chloroplast DNA of the flagellate E. gracilis induced by AO and ofloxacin (pt
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2003.09.001