Comparison of open and closed abdomen techniques for the delivery of intraperitoneal pemetrexed using a murine model

Background and Objectives Pemetrexed is an appealing agent to use for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the optimal method of pemetrexed delivery still remains undefined. Using a murine model, we compared the use of open and closed abdomen techniq...

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Bibliographic Details
Published in:Journal of surgical oncology 2018-05, Vol.117 (6), p.1318-1322
Main Authors: Badrudin, David, Sideris, Lucas, Perrault‐Mercier, Camille, Hubert, Julien, Leblond, François A., Dubé, Pierre
Format: Article
Language:English
Subjects:
Abdomen
Cancer surgery
experimental study
HIPEC
pemetrexed
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Summary:Background and Objectives Pemetrexed is an appealing agent to use for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). However, the optimal method of pemetrexed delivery still remains undefined. Using a murine model, we compared the use of open and closed abdomen techniques on the absorption of intraperitoneal (IP) pemetrexed in different compartments. Methods Eleven Sprague‐Dawley rats were submitted to a fixed dose of IP pemetrexed (1000 mg/m2) at a perfusion temperature of 40°C during 25 min according to two techniques: open and closed. At the end of perfusion, samples in different compartments were harvested and the concentrations of pemetrexed were measured by high performance liquid chromatography. Results Absorption of IP pemetrexed in portal and systemic blood was significantly higher using the open compared to the closed abdomen technique (93.17 vs 52.50 µg/mL, P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24960