Design of prospective antiparasitic metal-based compounds including selected organometallic cores

[Display omitted] •Efforts to develop organometallic agents against trypanosomatid parasites are reviewed.•Review focuses on American and African Trypanosomiasis and Leishmaniasis.•Review includes sections devoted to efforts grouped by type of organometallic core.•Efforts to modify structures based...

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Bibliographic Details
Published in:Inorganica Chimica Acta 2018-03, Vol.472, p.58-75
Main Authors: Gambino, D., Otero, L.
Format: Article
Language:English
Subjects:
African Trypanosomiasis
American Trypanosomiasis
Chemical compounds
Design modifications
Diagnostic systems
Drugs
Leishmaniasis
Metal-based drugs
Metals
Molecular chains
Molecular structure
Organic chemistry
Organometallic cores
Parasitic diseases
Protozoa
Public health
Qualitative reasoning
Target recognition
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Summary:[Display omitted] •Efforts to develop organometallic agents against trypanosomatid parasites are reviewed.•Review focuses on American and African Trypanosomiasis and Leishmaniasis.•Review includes sections devoted to efforts grouped by type of organometallic core.•Efforts to modify structures based on rational design are highlighted. A group of seventeen communicable and poverty-related diseases are considered neglected by the World Health Organization due to the restricted development of diagnostic methods, therapeutic treatments and/or control strategies. Among them three parasitic diseases caused by genetically related protozoa belonging to the trypanosomatid genus and kinetoplastida order are major health concerns in the developing world: American Trypanosomiasis (Chagas disease), Human African Trypanosomiasis and Leishmaniasis. This review focuses on efforts carried out to develop bioorganometallic compounds as prospective agents for the treatment of these diseases. It is divided in sections devoted to efforts grouped by type of organometallic core. Those series of compounds for which efforts have been done to modify structures through rational design, to get at least qualitative structure–activity relationships and to identify molecular targets and mode of action will be preferentially highlighted. Comments on potentialities, perspectives and tasks of bioorganometallic chemistry for the field of development of drugs against trypanosomatid parasites are also included.
ISSN:0020-1693
1873-3255
DOI:10.1016/j.ica.2017.07.068