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RECENT DEVELOPMENTS IN MOLECULAR GENETICS OF CANDIDA ALBICANS
The frequency of opportunistic infections caused by the fungus Candida albicans is very high and is expected to continue to increase as the number of immunocompromised patients rises. Research initiatives to study the biology of this organism and elucidate its pathogenic determinants have therefore...
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| Published in: | Annual review of microbiology 2000-01, Vol.54 (1), p.463-498 |
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| container_title | Annual review of microbiology |
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| creator | De Backer, Marianne D Magee, Paul T Pla, Jesus |
| description | The frequency of opportunistic infections caused by the fungus
Candida
albicans
is very high and is expected to continue to increase as the number
of immunocompromised patients rises. Research initiatives to study the biology
of this organism and elucidate its pathogenic determinants have therefore
expanded significantly during the last 5-10 years. The past few years
have also brought continuous improvement in the techniques to study gene
function by gene inactivation and by regulated gene expression and to study
gene expression and protein localization by using gene reporter systems. As
steadily more genomic sequence information from this human fungal pathogen
becomes available, we are entering a new era in antimicrobial research.
However, many of the currently available molecular genetics tools are poorly
adapted to a genome-wide functional analysis in
C. albicans
, and further
development of these tools is hampered by the asexual and diploid nature of
this organism. This review outlines recent advances in the development of
molecular tools for functional analysis in
C. albicans
and summarizes
current knowledge about the genomic and genetic variability of this important
human fungal pathogen. |
| doi_str_mv | 10.1146/annurev.micro.54.1.463 |
| format | article |
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Candida
albicans
is very high and is expected to continue to increase as the number
of immunocompromised patients rises. Research initiatives to study the biology
of this organism and elucidate its pathogenic determinants have therefore
expanded significantly during the last 5-10 years. The past few years
have also brought continuous improvement in the techniques to study gene
function by gene inactivation and by regulated gene expression and to study
gene expression and protein localization by using gene reporter systems. As
steadily more genomic sequence information from this human fungal pathogen
becomes available, we are entering a new era in antimicrobial research.
However, many of the currently available molecular genetics tools are poorly
adapted to a genome-wide functional analysis in
C. albicans
, and further
development of these tools is hampered by the asexual and diploid nature of
this organism. This review outlines recent advances in the development of
molecular tools for functional analysis in
C. albicans
and summarizes
current knowledge about the genomic and genetic variability of this important
human fungal pathogen.</description><identifier>ISSN: 0066-4227</identifier><identifier>EISSN: 1545-3251</identifier><identifier>DOI: 10.1146/annurev.micro.54.1.463</identifier><identifier>PMID: 11018135</identifier><identifier>CODEN: ARMIAZ</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Biological and medical sciences ; Candida albicans ; Candida albicans - genetics ; Candida albicans - pathogenicity ; Candidiasis ; expression ; Fundamental and applied biological sciences. Psychology ; Fungi ; Gene Expression ; gene function ; gene manipulation ; Genetic aspects ; Genetic Variation ; Genetics ; genome ; Genome, Fungal ; Genomics ; Growth, nutrition, metabolism, transports, enzymes. Molecular biology ; Health aspects ; Humans ; Microbiology ; Molecular Biology ; Molecular genetics ; Mycology ; Mycoses ; Recombinant Proteins - biosynthesis</subject><ispartof>Annual review of microbiology, 2000-01, Vol.54 (1), p.463-498</ispartof><rights>Copyright © 2000 by Annual Reviews. All rights reserved</rights><rights>2001 INIST-CNRS</rights><rights>COPYRIGHT 2000 Annual Reviews, Inc.</rights><rights>Copyright Annual Reviews, Inc. 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a573t-61757e473f235101e217e8c2de0e15992315264ac019d9b50fe4ea86fdb896f63</citedby><cites>FETCH-LOGICAL-a573t-61757e473f235101e217e8c2de0e15992315264ac019d9b50fe4ea86fdb896f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.micro.54.1.463?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.micro.54.1.463$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1051260$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11018135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Backer, Marianne D</creatorcontrib><creatorcontrib>Magee, Paul T</creatorcontrib><creatorcontrib>Pla, Jesus</creatorcontrib><title>RECENT DEVELOPMENTS IN MOLECULAR GENETICS OF CANDIDA ALBICANS</title><title>Annual review of microbiology</title><addtitle>Annu Rev Microbiol</addtitle><description>The frequency of opportunistic infections caused by the fungus
Candida
albicans
is very high and is expected to continue to increase as the number
of immunocompromised patients rises. Research initiatives to study the biology
of this organism and elucidate its pathogenic determinants have therefore
expanded significantly during the last 5-10 years. The past few years
have also brought continuous improvement in the techniques to study gene
function by gene inactivation and by regulated gene expression and to study
gene expression and protein localization by using gene reporter systems. As
steadily more genomic sequence information from this human fungal pathogen
becomes available, we are entering a new era in antimicrobial research.
However, many of the currently available molecular genetics tools are poorly
adapted to a genome-wide functional analysis in
C. albicans
, and further
development of these tools is hampered by the asexual and diploid nature of
this organism. This review outlines recent advances in the development of
molecular tools for functional analysis in
C. albicans
and summarizes
current knowledge about the genomic and genetic variability of this important
human fungal pathogen.</description><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Candida albicans - genetics</subject><subject>Candida albicans - pathogenicity</subject><subject>Candidiasis</subject><subject>expression</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungi</subject><subject>Gene Expression</subject><subject>gene function</subject><subject>gene manipulation</subject><subject>Genetic aspects</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>genome</subject><subject>Genome, Fungal</subject><subject>Genomics</subject><subject>Growth, nutrition, metabolism, transports, enzymes. Molecular biology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Microbiology</subject><subject>Molecular Biology</subject><subject>Molecular genetics</subject><subject>Mycology</subject><subject>Mycoses</subject><subject>Recombinant Proteins - biosynthesis</subject><issn>0066-4227</issn><issn>1545-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkV1r2zAUhs3YWNNuf6GYMXY1ezr6tBm98By3C7jJaNLdCsWWiotjZ5LTbf9-ymLoGIGgCx3Ec86rwxMEl4BiAMo_qa7bWf0Ub5rK9jGjMcSUkxfBBBhlEcEMXgYThDiPKMbiLDh37hEhRAVKXwdnAAgSIGwSXN0VeTFfhdPie1Euvt36ehnO5uHtoizy-zK7C2-KebGa5ctwcR3m2Xw6m2ZhVn6Z-Xr5JnhlVOv02_G-CO6vi1X-NSoXNx4oI8UEGSIOgglNBTGYMB-tMQidVLjWSANLU0yAYU5VhSCt0zVDRlOtEm7qdZJyw8lF8OEwd2v7HzvtBrlpXKXbVnW63zkpMEFCCHYSBCGIwHQPvvsPfOx3tvNLSIxY4mOR8NDHA_SgWi2bzvSDVdWD7rRVbd9p0_jnjCcYcCrA49ER3J9ae03HeH7gvULnrDZya5uNsr8lILm3LEfL8q9lyagE6S37xsvx87v1RtfPbaNWD7wfAeUq1Rqruqpx_4xngDny2OcDts9RrU9q9M9n7Hi63NZGDr-GU90ndvgDCuTWRw</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>De Backer, Marianne D</creator><creator>Magee, Paul T</creator><creator>Pla, Jesus</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>R05</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>RECENT DEVELOPMENTS IN MOLECULAR GENETICS OF CANDIDA ALBICANS</title><author>De Backer, Marianne D ; Magee, Paul T ; Pla, Jesus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a573t-61757e473f235101e217e8c2de0e15992315264ac019d9b50fe4ea86fdb896f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Candida albicans - genetics</topic><topic>Candida albicans - pathogenicity</topic><topic>Candidiasis</topic><topic>expression</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungi</topic><topic>Gene Expression</topic><topic>gene function</topic><topic>gene manipulation</topic><topic>Genetic aspects</topic><topic>Genetic Variation</topic><topic>Genetics</topic><topic>genome</topic><topic>Genome, Fungal</topic><topic>Genomics</topic><topic>Growth, nutrition, metabolism, transports, enzymes. Molecular biology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Microbiology</topic><topic>Molecular Biology</topic><topic>Molecular genetics</topic><topic>Mycology</topic><topic>Mycoses</topic><topic>Recombinant Proteins - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Backer, Marianne D</creatorcontrib><creatorcontrib>Magee, Paul T</creatorcontrib><creatorcontrib>Pla, Jesus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Backer, Marianne D</au><au>Magee, Paul T</au><au>Pla, Jesus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RECENT DEVELOPMENTS IN MOLECULAR GENETICS OF CANDIDA ALBICANS</atitle><jtitle>Annual review of microbiology</jtitle><addtitle>Annu Rev Microbiol</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>54</volume><issue>1</issue><spage>463</spage><epage>498</epage><pages>463-498</pages><issn>0066-4227</issn><eissn>1545-3251</eissn><coden>ARMIAZ</coden><abstract>The frequency of opportunistic infections caused by the fungus
Candida
albicans
is very high and is expected to continue to increase as the number
of immunocompromised patients rises. Research initiatives to study the biology
of this organism and elucidate its pathogenic determinants have therefore
expanded significantly during the last 5-10 years. The past few years
have also brought continuous improvement in the techniques to study gene
function by gene inactivation and by regulated gene expression and to study
gene expression and protein localization by using gene reporter systems. As
steadily more genomic sequence information from this human fungal pathogen
becomes available, we are entering a new era in antimicrobial research.
However, many of the currently available molecular genetics tools are poorly
adapted to a genome-wide functional analysis in
C. albicans
, and further
development of these tools is hampered by the asexual and diploid nature of
this organism. This review outlines recent advances in the development of
molecular tools for functional analysis in
C. albicans
and summarizes
current knowledge about the genomic and genetic variability of this important
human fungal pathogen.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>11018135</pmid><doi>10.1146/annurev.micro.54.1.463</doi><tpages>36</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4227 |
| ispartof | Annual review of microbiology, 2000-01, Vol.54 (1), p.463-498 |
| issn | 0066-4227 1545-3251 |
| language | eng |
| recordid | cdi_proquest_journals_205889607 |
| source | Annual Reviews |
| subjects | Biological and medical sciences Candida albicans Candida albicans - genetics Candida albicans - pathogenicity Candidiasis expression Fundamental and applied biological sciences. Psychology Fungi Gene Expression gene function gene manipulation Genetic aspects Genetic Variation Genetics genome Genome, Fungal Genomics Growth, nutrition, metabolism, transports, enzymes. Molecular biology Health aspects Humans Microbiology Molecular Biology Molecular genetics Mycology Mycoses Recombinant Proteins - biosynthesis |
| title | RECENT DEVELOPMENTS IN MOLECULAR GENETICS OF CANDIDA ALBICANS |
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