Antiulcerogenic activity of borneol derivatives

Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric...

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Bibliographic Details
Published in:Russian chemical bulletin 2018-03, Vol.67 (3), p.558-561
Main Authors: Borisova, M. S., Yarovaya, O. I., Semenova, M. D., Tolstikova, T. G., Salakhutdinov, N. F.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Ethanol
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Inorganic Chemistry
Organic Chemistry
Ulcers
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Summary:Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-018-2110-y