Management of In-Breast Tumor Recurrence

The management of isolated in-breast tumor recurrence is complex, requiring careful consideration of prior local therapies to plan future multimodality treatment. Options for surgical management have evolved from standard salvage mastectomy with axillary clearance and now include repeat breast conse...

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Bibliographic Details
Published in:Annals of surgical oncology 2018-10, Vol.25 (10), p.2846-2851
Main Authors: Wong, Stephanie M., Golshan, Mehra
Format: Article
Language:English
Subjects:
Axilla
Biopsy
Breast
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Breast Oncology
Chemotherapy
Clinical trials
Disease Management
Female
Humans
Lymph Node Excision
Lymph nodes
Mastectomy
Medicine
Medicine & Public Health
Morbidity
Neoplasm Recurrence, Local - surgery
Oncology
Patients
Prognosis
Surgery
Surgical Oncology
Toxicity
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Summary:The management of isolated in-breast tumor recurrence is complex, requiring careful consideration of prior local therapies to plan future multimodality treatment. Options for surgical management have evolved from standard salvage mastectomy with axillary clearance and now include repeat breast conservation with axillary staging in select patients. Reattempting sentinel lymph node biopsy may avoid the morbidity of extensive axillary surgery and has been shown to be feasible in clinically node-negative patients with oncologically safe outcomes. In the adjuvant setting, partial breast irradiation has emerged as a valuable means to improve local control rates with limited associated toxicity and acceptable overall cosmesis. Furthermore, results from prospective trials are now available to support the use of chemotherapy in hormone-receptor negative subgroups, which is associated with improvements in long-term, disease-free, and overall survival.
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-018-6605-4