Application of lithium ascorbate for regulation of lipid-cholesterol metabolism and glutathione redox system in pregnant sows

• Published in: Ukrainian journal of ecology 2018-05, Vol.8 (2), p.59-66
• Main Authors: Ostrenko, K S, Galochkina, V P, Galochkin, V A
• Format: Article
• Language: eng ; rus
• Subjects: Animal reproduction; Ascorbic acid; Biological fertilization; Biomass; Biotechnology; Body weight; Cholesterol; Cortisol; Data processing; Drugs; Dynamics; Ecology; Fertilization; Glutathione peroxidase; High density lipoprotein; Hogs; Hormones; Lipid metabolism; Lipids; Lipoproteins; Lipoproteins (very low density); Lithium; Low density lipoprotein; Metabolism; Methods; Oxidoreductions; Parameters; Physiology; Pork; Powder; Pregnancy; Progesterone; Proteins; Superoxide dismutase; Weight
• ISSN: 2520-2138
• DOI: 10.15421/2018_310

The study is aimed at developing a method for using a new, organic drug - lithium ascorbate. The aim of the work is to develop a new, more effective and more physiological way to combat all forms of stress in farm animals to increase productivity. Lithium ascorbate is an adaptogen preparation capable of becoming one of the new effective and physiological elements of pork production biotechnology rationalization. The experiment was carried out on 5 groups of pregnant sows of Landrace breed (4 experimental and 1 control sows) with 5 heads each. After 30 days of fruitful insemination of sows 1,2, 3 and 4 groups received daily with food lithium ascorbate in powder form in the dose of 10; 5; 2; 0.5 mg/kg of live weight, respectively. Weighing was carried out before the introduction of the drug. Repeated weighing was carried out in 2 and 3 months after fertilization and just before farrowing. In the blood plasma was determined dialdehyde, restored glutathione, oxidized glutathione, triacylglycerol, total cholesterol, total protein, lipoprotein fraction is HDL, LDL, VLDL, thiol-disulfide ratio (SH/SS); activity of superoxide dismutase and glutathione peroxidase. It is established that the introduction of feed sows at a dosage of 10, 5 and 2 mg/kg of body weight, ascorbate, lithium exhibits a pronounced adaptogen and stress-protection properties, supported on a physiological level, the dynamics of cortisol and progesterone during pregnancy. Lithium ascorbate contributes to increase of nonspecific resistance, growth of gestating sows, the tread in relation to technological and spontaneous stressors. The obtained data indicate that lithium ascorbate in sows in all studied parameters was effective, affecting lipid-cholesterol metabolism, glutathione reduction system and as a result, increasing the safety, live weight and reproductive function of sows. The experimental verification of the developed dose, scheme and method of administration, lithium ascorbate based on a set of biochemical and physiological parameters confirmed the validity of the proposed concept on the possibility of creating with its help new methods of effective and physiological management of behavioral reactions, non-specific resistance and productivity of animals.