Characterization of aspirated thrombi in patients with ST-elevation myocardial infarction

Objective: Recent studies have shown that exists an association between histological features of thrombi and major cardiovascular outcomes clinical in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to analyze structural features of coronary thrombi in STE...

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Bibliographic Details
Published in:Vascular pharmacology 2018-04, Vol.103-105, p.54-54
Main Authors: Del Turco, S., Sbrana, S., Pucci, A., Basta, G., Trianni, G., De Caterina, A.R., Rizza, A., Ravani, M., Palmieri, C., Berti, S., Mazzone, A.
Format: Article
Language:English
Subjects:
Age
Age factors
Collagen
Composition
Correlation analysis
Fibrin
Geriatrics
Heart attacks
Histology
Histopathology
Infiltration
Inflammation
Inflammatory response
Leukocytes
Lymphocytes
Monocytes
Myocardial infarction
Older people
Order parameters
Patients
Platelets
Thrombosis
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Summary:Objective: Recent studies have shown that exists an association between histological features of thrombi and major cardiovascular outcomes clinical in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to analyze structural features of coronary thrombi in STEMI patients and to evaluate the effects of age patients on coronary thrombus composition and routine measured laboratory parameters in acute phase of myocardial infarction. Methods: Coronary thrombi (n = 54) were removed by thrombo-aspiration in 123 patients presenting for primary percutaneous intervention and were analyzed by immunostaining and classified in fresh or older. Correlation between pathological characteristics of thrombi and clinical parameters were assessed. In order to evaluate the effect of age on thrombus composition, the population was divided into two groups using a cut-offof 65 years. Results: Older thrombi were present in 92% of patients with STEMI. Old thrombi were mainly composed of fibrin (39%), red cells (36%) and young collagen fibers (20%) and classified in lytic (n = 31) and organized (n = 19). No significant histopathological differences were found between lytic and organized thrombi (p = 0.54). Group I includes young-adult patients (age 65 years n = 25). On the other hand, group II exhibited a higher neutrophil-to-lymphocyte (N/L) blood ratio (p = 0.05) and a higher value of VES (p = 0.0015). The percentage of old/lytic and organized thrombi did not differ between two groups patients. Only, patients with age
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2017.12.019