The Complex Nature of Thermal Phase Transitions in Albumin Solutions

Dielectric and optical methods were used to reveal the complex nature of globule–coil–coil associate phase transitions in solutions of human serum albumin. The impedancemetric and nephelometric curves of temperature dependences of the parameters of the phase transitions in albumin that was introduce...

Full description

Saved in:
Bibliographic Details
Published in:Technical physics 2018-06, Vol.63 (6), p.908-915
Main Authors: Vonti, A. O., Il’inskii, A. V., Kapralova, V. M., Shadrin, E. B.
Format: Article
Language:English
Subjects:
Albumin
Biomedical Physics
Classical and Continuum Physics
Coils
Nervous system diseases
Optics
Phase transitions
Physics
Physics and Astronomy
Serum albumin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dielectric and optical methods were used to reveal the complex nature of globule–coil–coil associate phase transitions in solutions of human serum albumin. The impedancemetric and nephelometric curves of temperature dependences of the parameters of the phase transitions in albumin that was introduced into the standard saline were obtained. Impedancemetry revealed a two-stage mechanism of the globule–coil phase transition, and nephelometry established a two-stage mechanism of the coil–coil associate phase transition. The concentration dependences of the critical indices and temperatures were determined for both phase transitions.
ISSN:1063-7842
1090-6525
DOI:10.1134/S1063784218060245